Winstrol

[musclenz]

my winstrol brothers,

Under the tongue or just down the throat?

Inject

[I Declare War]

my winstrol brothers,

Under the tongue or just down the throat?

swallow it!

It's a rather large molecular weight compound and it's likely to be crystallised somewhat... as such I don't think it will absorb quickly under your tongue. It will need to make a first pass through the liver before it can become functional anyway... it's a 17-alpha alkylated oral steroid. The 17-aa feature of the molecule is like a barrier preventing the liver from breaking it down... the liver de-alkylates the compound and as a result the biologically active form of Winstrol is released into body (this then comes back for a second pass later on, when it's made its rounds, and gets broken down into its metabolites). So, down the hatch it goes.

Or you can inject... if you're sure it's sterile... remember water based steroids carry a much greater risk of causing an infection. Injection doesn't carry much benefit though, remember it's a water based depot... it will not last like an oil based depot. Even when injected winny will need to make a first pass through the liver for de-alkylation before becoming biologically active. No real benefits injecting in my opinion.

[bulking4ever]

I've closed my last Sus/D-bol cycle with Winny 100mg/EOD.

Around 20 days after finnishing I started feeling joint pain until it fucked my left shoulder. Also had blood work done, Doctor looked at me and said: ''You're pretty young to have such bad Cholesterol''

My liver enzymes were rather fucked as well.

One thing I noticed is that when I used the oral W in the past, my urine was really cloudy, not so much this time. Don't really know why.

Apart from that, No sides like hair loss or acne, and I loved the hard and dry look it gave me.

[thatwaslight]

Fellas, thoughts on 100mg winny depot orally ed? Is this too toxic a dose to run for 5 weeks? (im looking at you mnz ect)

[train_insane]

f*ck that shit, gives me acne hard im off it forever my face is too precious lol

[DANIEL8]

f*ck that shit, gives me acne hard im off it forever my face is too precious lol

easy fix bro, splurge out and buy some gh

[thatwaslight]

so 100mg ed? good night sweet liver or not?

[Android]

so 100mg ed? good night sweet liver or not?

It's too hard to tell mate.

How will you know during or just after the cycle if you did damage a portion of it?

You won't know for years down the track because it'll keep functioning with what's left undamaged. None of us really know the answer (except Tom)

[I Declare War]

TWL, you'll be in the fast lane, on the highway to hell. 8)

Since you're already running Dbol... Just run it a bit lower and keep some for later on?

[tomsammce]

so 100mg ed? good night sweet liver or not?

It's too hard to tell mate.

How will you know during or just after the cycle if you did damage a portion of it?

You won't know for years down the track because it'll keep functioning with what's left undamaged. None of us really know the answer (except Tom)

No You dont know the answer because like usual you dont know what your talking about.

anyway, a 4-6 week cycle of 100mg/day of oral winny will be fine, obviously you dont want to run it longterm so dont take any orals or go on any big benders after the cycle and your liver will repair itself, even if u damage 60-80% of liver cells in that time if nothing else arises then your liver will completly repair itself and a liver biopsy after around 30 days will show completely normal with no signs of damage and no scarring. the long term liver damage happens when you dont give it a chance to regenerate itself by using a drug or alcohol which continuously attacks the liver and prevents complete regeneration resulting in scar tissue. once u got scar tissue in liver its very hard to reverse that and major scarring of the liver is known as Cirrhosis. once you got that its a late stage sign of liver discease and your fucked usually by the onset of all sorts of complications.

the livers the only organ in the body thats able to fully regenerate itself from pretty much fully fucked with new cells rather than a scar (like on the skin). so treat it with respect but its a pretty amazing thing and alot of people fo underestimate it (not advocating high dosages of orals) but the people who say 40mg/day max dbol for 6 weeks really have no idea and its about as factual as the person who made up 8 hours sleep a night.

[Daz69]

so 100mg ed? good night sweet liver or not?

It's too hard to tell mate.

How will you know during or just after the cycle if you did damage a portion of it?

You won't know for years down the track because it'll keep functioning with what's left undamaged. None of us really know the answer (except Tom)

No You dont know the answer because like usual you dont know what your talking about.

anyway, a 4-6 week cycle of 100mg/day of oral winny will be fine, obviously you dont want to run it longterm so dont take any orals or go on any big benders after the cycle and your liver will repair itself, even if u damage 60-80% of liver cells in that time if nothing else arises then your liver will completly repair itself and a liver biopsy after around 30 days will show completely normal with no signs of damage and no scarring. the long term liver damage happens when you dont give it a chance to regenerate itself by using a drug or alcohol which continuously attacks the liver and prevents complete regeneration resulting in scar tissue. once u got scar tissue in liver its very hard to reverse that and major scarring of the liver is known as Cirrhosis. once you got that its a late stage sign of liver disease and your fucked usually by the onset of all sorts of complications.

the livers the only organ in the body thats able to fully regenerate itself from pretty much fully fucked with new cells rather than a scar (like on the skin). so treat it with respect but its a pretty amazing thing and alot of people fo underestimate it (not advocating high dosages of orals) but the people who say 40mg/day max dbol for 6 weeks really have no idea and its about as factual as the person who made up 8 hours sleep a night.

A very informative post again Tom (the liver specialist)...... :grin:

Not always acted on the side of caution myself but, TWL is already on:

400 Tren

800 Test

25mg Dbol

We all know Winstrol is pretty harsh on the liver... But thats the tablets..

TWL mentioned taking winstrol depot orally, which from memory is the white water based stuff.... Same 17 alpha-alkylated compound but works slightly different when injected to taken orally...... I believe when injected you benefit from greater nitrogen retention, and orally doses as low as 18-20mg/day have been shown to reduce SHBG by as much as 50%..

But whether this applies to taking the injectable version orally I don't know, but as its the same compound I might be inclined to think it would...

I don't know why TWL would want to take 100mg/day on top of what he is already taking, I suppose it depends what he is trying to achieve..?

20mg/day seems sensible to lower SHBG to me....

Any more, on top of everything else & what's the point...?

More compounds don't always mean more gains, but they do get you more side effects...

Maybe that's why you're all complaining of man-boobs......... :pfft:

[I Declare War]

It's too hard to tell mate.

How will you know during or just after the cycle if you did damage a portion of it?

You won't know for years down the track because it'll keep functioning with what's left undamaged. None of us really know the answer (except Tom)

No You dont know the answer because like usual you dont know what your talking about.

anyway, a 4-6 week cycle of 100mg/day of oral winny will be fine, obviously you dont want to run it longterm so dont take any orals or go on any big benders after the cycle and your liver will repair itself, even if u damage 60-80% of liver cells in that time if nothing else arises then your liver will completly repair itself and a liver biopsy after around 30 days will show completely normal with no signs of damage and no scarring. the long term liver damage happens when you dont give it a chance to regenerate itself by using a drug or alcohol which continuously attacks the liver and prevents complete regeneration resulting in scar tissue. once u got scar tissue in liver its very hard to reverse that and major scarring of the liver is known as Cirrhosis. once you got that its a late stage sign of liver disease and your fucked usually by the onset of all sorts of complications.

the livers the only organ in the body thats able to fully regenerate itself from pretty much fully fucked with new cells rather than a scar (like on the skin). so treat it with respect but its a pretty amazing thing and alot of people fo underestimate it (not advocating high dosages of orals) but the people who say 40mg/day max dbol for 6 weeks really have no idea and its about as factual as the person who made up 8 hours sleep a night.

A very informative post again Tom (the liver specialist)...... :grin:

Not always acted on the side of caution myself but, TWL is already on:

400 Tren

800 Test

25mg Dbol

We all know Winstrol is pretty harsh on the liver... But thats the tablets..

TWL mentioned taking winstrol depot orally, which from memory is the white water based stuff.... Same 17 alpha-alkylated compound but works slightly different when injected to taken orally...... I believe when injected you benefit from greater nitrogen retention, and orally doses as low as 18-20mg/day have been shown to reduce SHBG by as much as 50%..

But whether this applies to taking the injectable version orally I don't know, but as its the same compound I might be inclined to think it would...

I don't know why TWL would want to take 100mg/day on top of what he is already taking, I suppose it depends what he is trying to achieve..?

20mg/day seems sensible to lower SHBG to me....

Any more, on top of everything else & what's the point...?

More compounds don't always mean more gains, but they do get you more side effects...

Maybe that's why you're all complaining of man-boobs......... :pfft:

When taken orally or injected it still needs to make that first pass through the liver to get de-alkylated. So, it's the same either way. It's slightly more efficient when injected though as it doesn't have to go through digestive system first - that's why a slightly smaller dosage is needed to get the same result that you'd get from ingesting it.

[HarryB]

No You dont know the answer because like usual you dont know what your talking about.

anyway, a 4-6 week cycle of 100mg/day of oral winny will be fine, obviously you dont want to run it longterm so dont take any orals or go on any big benders after the cycle and your liver will repair itself, even if u damage 60-80% of liver cells in that time if nothing else arises then your liver will completly repair itself and a liver biopsy after around 30 days will show completely normal with no signs of damage and no scarring. the long term liver damage happens when you dont give it a chance to regenerate itself by using a drug or alcohol which continuously attacks the liver and prevents complete regeneration resulting in scar tissue. once u got scar tissue in liver its very hard to reverse that and major scarring of the liver is known as Cirrhosis. once you got that its a late stage sign of liver disease and your fucked usually by the onset of all sorts of complications.

the livers the only organ in the body thats able to fully regenerate itself from pretty much fully fucked with new cells rather than a scar (like on the skin). so treat it with respect but its a pretty amazing thing and alot of people fo underestimate it (not advocating high dosages of orals) but the people who say 40mg/day max dbol for 6 weeks really have no idea and its about as factual as the person who made up 8 hours sleep a night.

A very informative post again Tom (the liver specialist)...... :grin:

Not always acted on the side of caution myself but, TWL is already on:

400 Tren

800 Test

25mg Dbol

We all know Winstrol is pretty harsh on the liver... But thats the tablets..

TWL mentioned taking winstrol depot orally, which from memory is the white water based stuff.... Same 17 alpha-alkylated compound but works slightly different when injected to taken orally...... I believe when injected you benefit from greater nitrogen retention, and orally doses as low as 18-20mg/day have been shown to reduce SHBG by as much as 50%..

But whether this applies to taking the injectable version orally I don't know, but as its the same compound I might be inclined to think it would...

I don't know why TWL would want to take 100mg/day on top of what he is already taking, I suppose it depends what he is trying to achieve..?

20mg/day seems sensible to lower SHBG to me....

Any more, on top of everything else & what's the point...?

More compounds don't always mean more gains, but they do get you more side effects...

Maybe that's why you're all complaining of man-boobs......... :pfft:

When taken orally or injected it still needs to make that first pass through the liver to get de-alkylated. So, it's the same either way. It's slightly more efficient when injected though as it doesn't have to go through digestive system first - that's why a slightly smaller dosage is

needed to get the same result that you'd get from ingesting it.

Anyone know what the uptake is when you take something orally? I read somewhere it was 25% under optimal conditions hence injectables being so much more effective. Not just Steroids but all meds.

[I Declare War]

A very informative post again Tom (the liver specialist)...... :grin:

Not always acted on the side of caution myself but, TWL is already on:

400 Tren

800 Test

25mg Dbol

We all know Winstrol is pretty harsh on the liver... But thats the tablets..

TWL mentioned taking winstrol depot orally, which from memory is the white water based stuff.... Same 17 alpha-alkylated compound but works slightly different when injected to taken orally...... I believe when injected you benefit from greater nitrogen retention, and orally doses as low as 18-20mg/day have been shown to reduce SHBG by as much as 50%..

But whether this applies to taking the injectable version orally I don't know, but as its the same compound I might be inclined to think it would...

I don't know why TWL would want to take 100mg/day on top of what he is already taking, I suppose it depends what he is trying to achieve..?

20mg/day seems sensible to lower SHBG to me....

Any more, on top of everything else & what's the point...?

More compounds don't always mean more gains, but they do get you more side effects...

Maybe that's why you're all complaining of man-boobs......... :pfft:

When taken orally or injected it still needs to make that first pass through the liver to get de-alkylated. So, it's the same either way. It's slightly more efficient when injected though as it doesn't have to go through digestive system first - that's why a slightly smaller dosage is

needed to get the same result that you'd get from ingesting it.

Anyone know what the uptake is when you take something orally? I read somewhere it was 25% under optimal conditions hence injectables being so much more effective. Not just Steroids but all meds.

It'd vary from compound to compound... all depends on how well the med can withstand the acidic environment of the digestive system, the enzymes in there, and how well it's absorbed through into the bloodstream.

[HarryB]

When taken orally or injected it still needs to make that first pass through the liver to get de-alkylated. So, it's the same either way. It's slightly more efficient when injected though as it doesn't have to go through digestive system first - that's why a slightly smaller dosage is

needed to get the same result that you'd get from ingesting it.

Anyone know what the uptake is when you take something orally? I read somewhere it was 25% under optimal conditions hence injectables being so much more effective. Not just Steroids but all meds.

It'd vary from compound to compound... all depends on how well the med can withstand the acidic environment of the digestive system, the enzymes in there, and how well it's absorbed through into the bloodstream.

Yeah the article I was reading was about medicines not steroids per se and it was related to how well they travel through the digestive process and their ineffectiveness when compared to injected medications. And the 25% absorption was in optimal conditions.

I read it years ago and hardly ever take orals now because of it. Damned if it was a lie, all the dbol I could have taken ha ha ha

[Daz69]

When taken orally or injected it still needs to make that first pass through the liver to get de-alkylated. So, it's the same either way. It's slightly more efficient when injected though as it doesn't have to go through digestive system first - that's why a slightly smaller dosage is needed to get the same result that you'd get from ingesting it.

I've an article here that better explains what you were saying:

When you consume a drug orally, that drug is absorbed from the Gastrointestinal tract, where it then passes via the portal vein into the Liver -where some drugs are metabolised. This “first pass” can mean that only a certain portion of the drug reaches your body’s bloodstream. A 17 alpha-alkylated has been attached to winstrol to allow a sizeable portion to survive this metabolism.

First pass metabolism can occur in both the gut and the Liver, and where this happens can vary with different drugs. First pass metabolism actually occurs in your gut for some drugs and in the Liver for others. Once it has been metabolized, it enters the bloodstream. It’s important to note that when a drug is metabolized in the Gastrointestinal tract, the blood leaving the Gastrointestinal tract does not go right to the heart, but actually still passes through Liver via the hepatic portal vein and then ultimately returns to circulation via the hepatic vein. The Liver is your body’s filtration unit, and removes large quantities of nutrients, dangerous toxins (or fun toxins, depending on what they are) and other substances from the blood.

So as you can see, when you take an oral steroid such as winstrol, undergoes a first-pass metabolism in the both the intestines as well as Liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity, while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug then circulates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the Liver again, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of winstrol, an injectable version is available, and when we compare the oral and injectable versions of winstrol and their effects in your body, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and only undergoes the far less extensive second pass metabolism, while the oral must endure the gut and Liver on it’s first pass before ending up in circulation.

Now, here’s the interesting part: When you inject winstrol, instead of taking it orally, you actually get more nitrogen retention (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use winstrol to build new muscle tissue, the injectable version is going to be far superior to the Oral version. However, there are some advantages that the oral version has over the injectable, including a possible “synergy” with other drugs- but only (primarily) when taken orally. A fairly conservative oral dose of .2mg/kg of winstrol has been shown to lower sex hormone binding globulin by close to 50%. ............

[I Declare War]

You've got an article for everything, Daz69.

[Daz69]

You've got an article for everyhing, Daz69.

I just wish I understood em a bit more.......... :pfft: :pfft: :pfft:

[I Declare War]

You've got an article for everyhing, Daz69.

I just wish I understood em a bit more.......... :pfft: :pfft: :pfft:

Ah, so it doesn't go through the first pass when injected... but, it still needs to be de-alkylated at the 17-aa position for it to become biologically active.

[I Declare War]

Add this one to your database, Daz69...

Winstrol - Oral versus Injectable (More Different Than You Think!)

By Anthony Roberts

I tend to shy away from straight “information” articles- in other words, I’ve never written the “How Androgens Work” article, because I’ve read it several times by several authors, and I really have nothing to add. Gene Transcription and Androgen Receptor Action has been written about over, and over, ad nauseum. All of the articles I’ve read on the topic are well written and well- they’re all the same. Don’t get me wrong, all of the articles which discuss the topic are very informative, but when you’re done reading them, you don’t really have anything you can “use” in your next cycle.

And I’m sure you know the difference between orals and injectables, but do yourself a favor and read this article, because I’m going to explain some things in here that you can use in your next cycle. Actually, I’m going to explain how you can use Winstrol (Stanozolol) as either an oral or injectable, and get a very different set of effects from the same drug- depending on which route of administration you choose to utilize.

First, lets go over the basics of Winstrol, so we’re all on the same page here.

Winstrol is a steroid derived from the base structure of Dihydrotestosterone (DHT). DHT is just testosterone which has been 5alpha-reduced, meaning it has had the c4-5 double bond removed by two hydrogen atoms. This is very interesting from a chemical/biological standpoint. Once this bond is removed, testosterone has become DHT, and DHT is the body’s most potent androgen. DHT has a slew of beneficial effects which are more pronounced than the hormone it’s created out of. DHT is able to increase androgen receptor proliferation for almost 24 full hours (1) DHT also has profound effects on the Central Nervous System (CNS), and this is why we often see profoundly increased aggression with athletes who are using DHT derivatives such as Masteron (which has a deceivingly low anabolic and androgenic rating). As an added benefit, DHT can not aromatize (convert via the aromatase enzyme) into estrogen. It’s also noteworthy that the injectable version of Winstrol is actually the same exact thing as the oral- it’s just micronized Stanozolol powder suspended in water (or sometimes oil).

So what we have in Winstrol is DHT with two modifications- an added c17 methylation, and a very weird “pyrazol” group. The c17 methylation has been added in order to allow Winstrol to survive oral ingestion and the subsequent first pass through the liver. The pyrazol group is a bit weirder- what this means to you and I is that it has another whole “ring” attached to the four ring Steran Nucleus of DHT. Take a look over at the lower left portion of the two molecules below, and you’ll notice that Winstrol has an added cyclopentane (5 sided) group (the pyrazol group):

When we really take a look at Winstrol, the anabolic rating of this product is very high (320% that of testosterone) as compared to its androgenic actions (30% of testosterone). Despite this, Winstrol is really a disappointing drug for size gains. What we typically see with this stuff is some pretty decent strength gains and some nice fat loss if the user isn’t too sloppy with their diet. Not many people report huge weight gains off of Stanozolol. Although many drugs which bind tightly to the androgen receptor are suspected to exhibit their at least some of their lipolytic (fat-burning) effects through receptor binding affinity. The effects of androgens on the regulation of lipolysis in adipose precursor cells.(2), Winstrol remains a potent cutting drug, despite the fact that it has a relatively weak AR binding ability (3). What this tells me is that there’s some stuff going on with regards to Winstrol’s mechanism of action, which doesn’t involve androgen receptor mediated effects. Still, Winstrol is a very potent compound for enhancing protein synthesis (4-5 ) .

As previously discussed, it’s derived from DHT, and DHT is known to have ant-estrogenic effects (6) and Winstrol itself also has anti-progestenic properties (in at least some cases, where it may "block" that receptor) (7). So I think it’s safe to say that some of the “hard” look you can get in your physique from Winstrol is because of it’s ability to inhibit estrogen and progesterone- known culprits in making a physique appear smooth. Unfortunately, since it is 17aa, it is also liver toxic, especially more so when you inject it and it is subject to what is known as the “first pass” through the liver. The difference between taking oral vs. injectable Winstrol, even though it’s technically the same drug, is how and when your body metabolizes it. When you consume a drug orally, that drug is absorbed from the Gastrointestinal tract, where it then passes via the portal vein into the liver -where some drugs are metabolised. This “first pass” can mean that only a certain portion of the drug reaches your body’s bloodstream. As previously discussed, a 17aa has been attached to Winstrol to allow a sizeable portion to survive this metabolism.

First pass metabolism can occur in both the gut and the liver, and where this happens can vary with different drugs. First pass metabolism actually occurs in your gut for some drugs and in the liver for others. Once it has been metabolized, it enters the bloodstream. It’s important to note that when a blood is metabolized in the Gastrointestinal tract, the blood leaving the Gastrointestinal tract does not go right to the heart, but actually still passes through liver via the hepatic portal vein and then ultimately returns to circulation via the hepatic vein. The liver is your body’s filtration unit, and removes large quantities of nutrients, dangerous toxins (or fun toxins, depending on what they are) and other substances from the blood.

So as you can see, when you take an oral steroid such as Winstrol, undergoes a first-pass metabolism in the both the intestines as well as liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity, while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug then circulates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the liver again, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of Winstrol, an injectable version is available, and when we compare the oral and injectable versions of Winstrol and their effects in your body, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and only undergoes the far less extensive second pass metabolism, while the oral must endure the gut and liver on it’s first pass before ending up in circulation.

Now, here’s the interesting part: When you inject Winstrol, instead of taking it orally, you actually get more nitrogen retention (4) (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use Winstrol to build new muscle tissue, the injectable version is going to be far superior to the Oral version. However, there are some advantages that the oral version has over the injectable, including a possible “synergy” with other drugs- but only (primarily) when taken orally.

While in the liver, on it’s first pass, Winstrol is exposed to a variety of enzymes and proteins. To understand how a possible synergy between Winstrol and other steroids may be possible, a little background on Sex Hormone Binding Globulin (SHBG) is first necessary. For our purposes here, all we need to know is that SHBG is a glycoprotein produced in the liver, which binds to testosterone and makes it biologically unavailable to do all the things we want it to do- like building muscle. It serves to transport testosterone throughout the body, but while it remains bound to testosterone, the testosterone can not exert it’s anabolic effects.

As you can surmise, a very large portion of the testosterone in your body is bound to SHBG. Wouldn’t it be great if we could lower SHBG? With Winstrol we can.

A fairly conservative oral dose of .2mg/kg of Winstrol has been shown to lower SHBG by close to 50%. (8)For me (200lbs) this would mean I would only need around 18mgs/day to free up half of my SHBG bound testosterone! For my omnipresent and hypothetical “100kg bodybuilder”- only 20mgs would be needed (he’s 220 lbs for the metrically impaired among us). Now, with less SHBG floating around in me, my anabolic steroid cycle will be more effective, right? Right.

But why can we only expect such a dramatic lowering of SHBG with the oral? Well, obviously, we’re taking advantage of the first pass through the liver, where we can have our Winstrol interact with SHBG where it’s produced- in the liver…without going through the bloodstream first.

When we take a look at a study done comparing injectable vs. oral contraceptives, we find that the oral version at 70mgs/week (10mgs/day given orally) is more effective at affecting SHBG levels than 400mgs/week given via an injection! (9)In this study, testosterone undecanoate was given at a constant dose along with norestisterone (which raises SHBG). What we see is that when norestisterone is given orally, it produces a far greater effect on SHBG, than when it is administered via an injection. And this is even when the doses of the injectable are 4x higher!

Here’s a chart, illustrating exactly what I’m talking about in this study, which I think suggests very strongly that injectable versions of drugs, when compared with the oral version, will have nowhere near as much of an effect on SHBG:

Of course, in this study, they’re looking at oral vs. injectable versions of a SHBG raising drug- but what we can take away from it is that SHBG interaction with oral compounds is far more pronounced than it is with injectables.

So lets take a small amount of Winstrol with our cycles, and free up some of those steroids we’re taking, right? Right!

Unless of course, we’re talking about women here…I was recently asked why I recommend that women use the injectable version of Winstrol over the oral. I was asked this question by someone, who I assumed had a female friend who was considering using Winstrol. I then realized I was totally incorrect- not about Winstrol, but about the reason behind the question. You see…I saw a picture of the man who had first asked me the question, and it’s readily apparent to me that he probably doesn’t actually know any women. But still, his question is valid and bears repeating and answering here.

I recommend that women avoid the oral version of this product for the same reason that men will find that it gives them an increased synergy and effectiveness in their cycles.

When SHBG is lowered in women, there is more free testosterone floating around. And as we’ve seen, the oral is going to affect SHBG exponentially more than the injectable will. When we lower SHBG too much in women, we see a strong positive correlation with hyperandrogenism (10 ), and hirsuitism (abnormal growth of body hair), as well In fact, non-SHBG-bound testosterone may actually be the defining characteristic for identifying hyperandrogenism in women. In addition, low SHBG contributes to menstrual irregularity.(11)

Finally, and (partially) anecdotally, we also see a greater incidence of clitoral enlargement and acne when the oral version of Winstrol is used by women instead of the injectable. The reasons for this are obvious- When we increase free testosterone by lowering SHBG, we increase the amount of testosterone which is able to be 5a-reduced to DHT. DHT is the primary culprit for steroid induced acne, and is also the hormone responsible for external genital enlargement. Clearly, this is why we see the increased level of clitoral hypertrophy as well as acne when oral Winstrol is used by women.

We can also see increased acne when men use Winstrol orally, but these effects are relatively minor when a 2mg/kg dose is being used to increase the effectiveness of other steroids in a cycle. This isn’t carte blanche to go using Winstrol for an extended period of time under the excuse that it’s increasing the overall effectiveness of the cycle. Stanozolol has some of the worst liver toxicity (hepatoxicity) of any oral steroid on a mg for mg basis. In addition, it’s deleterious effects on your lipid profile (Cholesterol) are also very pronounced, even at low doses- 6mgs/day of Stanozolol can lower HDL (good cholesterol)by 33% and raise LDL (bad cholesterol) by 29% (12 ).

So, hopefully, you’ve reached the end of this article and realized that Winstrol can be used in any cycle to increase the effectiveness of it, but that it must be used sparingly due to it’s possible hepatoxicity and lipid profile effecting properties. Still, when used in heavy testosterone-based profiles, at a dose that will cut your SHBG levels in half, it can increase you other steroids effectiveness quite a bit…but when maximal protein synthesis is wanted, you need to inject it.

There you go…the differences between oral and injectable Winstrol, and how you can use either form to maximize your gains! And yes, Lyle, you can drink Winny.

References:

1. Neural Androgen Receptor Regulation: effects of androgen and antiandrogen. Lu S, Simon NG, Wang Y, Hu S, J Neurobiol 1999 Dec; 41(4):505-12

2. Endocrinology. 1990 Feb;126(2):1229-34. Xu X, De Pergola G, Bjorntorp P

3. Endocrinology. 1984 Jun;114(6):2100-6.

4. Can J Vet Res. 2000 Oct;64(4):246-8.

5. J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22

6. MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK 1979 Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab 49:905–916

7. Agents Actions. 1994 Mar;41(1-2):37-43.

8. Sex Hormone Binding Globulin response to the Anabolic steroid: Stanozolol: Evidence for its suitability as a Biological Androgen Sensitivity test. J Clin Metab Endocrinol 68: 1195, 1989)

9. The Journal of Clinical Endocrinology & Metabolism Vol. 87,No. 2 530-539. An Effective Hormonal Male Contraceptive Using Testosterone Undecanoate with Oral or Injectable Norethisterone Preparations Axel Kamischke, Tanja Heuermann, Kathrin Krüger, Sigrid von Eckardstein, Ilka Schellschmidt, Alexander Rübig and Eberhard Nieschlag Institute of Reproductive Medicine of the University (A.K., T.H., K.K., S.V.E., E.N.), D-48129 Münster, Germany; and Schering AG (I.S., A.R.), D-13342 Berlin, Germany

10. Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism DC Cumming and SR Wall J. Clin. Endocrinol. Metab., Nov 1985; 61: 873 - 876.

11. Menstrual Irregularity in Women with Acromegaly G. A. Kaltsas, J. J. Mukherjee, P. J. Jenkins, M. A. Satta, N. Islam, J. P. Monson, G. M. Besser, and A. B. GrossmanJ. Clin. Endocrinol. Metab., Aug 1999; 84: 2731 – 2735

12. JAMA. 1989 Feb 24;261(Cool:1165-8

[Daz69]

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Winstrol - Oral versus Injectable (More Different Than You Think!)

By Anthony Roberts

I tend to shy away from straight “information” articles- in other words, I’ve never written the “How Androgens Work” article, because I’ve read it several times by several authors, and I really have nothing to add. Gene Transcription and Androgen Receptor Action has been written about over, and over, ad nauseum. All of the articles I’ve read on the topic are well written and well- they’re all the same. Don’t get me wrong, all of the articles which discuss the topic are very informative, but when you’re done reading them, you don’t really have anything you can “use” in your next cycle.

And I’m sure you know the difference between orals and injectables, but do yourself a favor and read this article, because I’m going to explain some things in here that you can use in your next cycle. Actually, I’m going to explain how you can use Winstrol (Stanozolol) as either an oral or injectable, and get a very different set of effects from the same drug- depending on which route of administration you choose to utilize.

First, lets go over the basics of Winstrol, so we’re all on the same page here.

Winstrol is a steroid derived from the base structure of Dihydrotestosterone (DHT). DHT is just testosterone which has been 5alpha-reduced, meaning it has had the c4-5 double bond removed by two hydrogen atoms. This is very interesting from a chemical/biological standpoint. Once this bond is removed, testosterone has become DHT, and DHT is the body’s most potent androgen. DHT has a slew of beneficial effects which are more pronounced than the hormone it’s created out of. DHT is able to increase androgen receptor proliferation for almost 24 full hours (1) DHT also has profound effects on the Central Nervous System (CNS), and this is why we often see profoundly increased aggression with athletes who are using DHT derivatives such as Masteron (which has a deceivingly low anabolic and androgenic rating). As an added benefit, DHT can not aromatize (convert via the aromatase enzyme) into estrogen. It’s also noteworthy that the injectable version of Winstrol is actually the same exact thing as the oral- it’s just micronized Stanozolol powder suspended in water (or sometimes oil).

So what we have in Winstrol is DHT with two modifications- an added c17 methylation, and a very weird “pyrazol” group. The c17 methylation has been added in order to allow Winstrol to survive oral ingestion and the subsequent first pass through the liver. The pyrazol group is a bit weirder- what this means to you and I is that it has another whole “ring” attached to the four ring Steran Nucleus of DHT. Take a look over at the lower left portion of the two molecules below, and you’ll notice that Winstrol has an added cyclopentane (5 sided) group (the pyrazol group):

When we really take a look at Winstrol, the anabolic rating of this product is very high (320% that of testosterone) as compared to its androgenic actions (30% of testosterone). Despite this, Winstrol is really a disappointing drug for size gains. What we typically see with this stuff is some pretty decent strength gains and some nice fat loss if the user isn’t too sloppy with their diet. Not many people report huge weight gains off of Stanozolol. Although many drugs which bind tightly to the androgen receptor are suspected to exhibit their at least some of their lipolytic (fat-burning) effects through receptor binding affinity. The effects of androgens on the regulation of lipolysis in adipose precursor cells.(2), Winstrol remains a potent cutting drug, despite the fact that it has a relatively weak AR binding ability (3). What this tells me is that there’s some stuff going on with regards to Winstrol’s mechanism of action, which doesn’t involve androgen receptor mediated effects. Still, Winstrol is a very potent compound for enhancing protein synthesis (4-5 ) .

As previously discussed, it’s derived from DHT, and DHT is known to have ant-estrogenic effects (6) and Winstrol itself also has anti-progestenic properties (in at least some cases, where it may "block" that receptor) (7). So I think it’s safe to say that some of the “hard” look you can get in your physique from Winstrol is because of it’s ability to inhibit estrogen and progesterone- known culprits in making a physique appear smooth. Unfortunately, since it is 17aa, it is also liver toxic, especially more so when you inject it and it is subject to what is known as the “first pass” through the liver. The difference between taking oral vs. injectable Winstrol, even though it’s technically the same drug, is how and when your body metabolizes it. When you consume a drug orally, that drug is absorbed from the Gastrointestinal tract, where it then passes via the portal vein into the liver -where some drugs are metabolised. This “first pass” can mean that only a certain portion of the drug reaches your body’s bloodstream. As previously discussed, a 17aa has been attached to Winstrol to allow a sizeable portion to survive this metabolism.

First pass metabolism can occur in both the gut and the liver, and where this happens can vary with different drugs. First pass metabolism actually occurs in your gut for some drugs and in the liver for others. Once it has been metabolized, it enters the bloodstream. It’s important to note that when a blood is metabolized in the Gastrointestinal tract, the blood leaving the Gastrointestinal tract does not go right to the heart, but actually still passes through liver via the hepatic portal vein and then ultimately returns to circulation via the hepatic vein. The liver is your body’s filtration unit, and removes large quantities of nutrients, dangerous toxins (or fun toxins, depending on what they are) and other substances from the blood.

So as you can see, when you take an oral steroid such as Winstrol, undergoes a first-pass metabolism in the both the intestines as well as liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity, while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug then circulates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the liver again, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of Winstrol, an injectable version is available, and when we compare the oral and injectable versions of Winstrol and their effects in your body, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and only undergoes the far less extensive second pass metabolism, while the oral must endure the gut and liver on it’s first pass before ending up in circulation.

Now, here’s the interesting part: When you inject Winstrol, instead of taking it orally, you actually get more nitrogen retention (4) (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use Winstrol to build new muscle tissue, the injectable version is going to be far superior to the Oral version. However, there are some advantages that the oral version has over the injectable, including a possible “synergy” with other drugs- but only (primarily) when taken orally.

While in the liver, on it’s first pass, Winstrol is exposed to a variety of enzymes and proteins. To understand how a possible synergy between Winstrol and other steroids may be possible, a little background on Sex Hormone Binding Globulin (SHBG) is first necessary. For our purposes here, all we need to know is that SHBG is a glycoprotein produced in the liver, which binds to testosterone and makes it biologically unavailable to do all the things we want it to do- like building muscle. It serves to transport testosterone throughout the body, but while it remains bound to testosterone, the testosterone can not exert it’s anabolic effects.

As you can surmise, a very large portion of the testosterone in your body is bound to SHBG. Wouldn’t it be great if we could lower SHBG? With Winstrol we can.

A fairly conservative oral dose of .2mg/kg of Winstrol has been shown to lower SHBG by close to 50%. (8)For me (200lbs) this would mean I would only need around 18mgs/day to free up half of my SHBG bound testosterone! For my omnipresent and hypothetical “100kg bodybuilder”- only 20mgs would be needed (he’s 220 lbs for the metrically impaired among us). Now, with less SHBG floating around in me, my anabolic steroid cycle will be more effective, right? Right.

But why can we only expect such a dramatic lowering of SHBG with the oral? Well, obviously, we’re taking advantage of the first pass through the liver, where we can have our Winstrol interact with SHBG where it’s produced- in the liver…without going through the bloodstream first.

When we take a look at a study done comparing injectable vs. oral contraceptives, we find that the oral version at 70mgs/week (10mgs/day given orally) is more effective at affecting SHBG levels than 400mgs/week given via an injection! (9)In this study, testosterone undecanoate was given at a constant dose along with norestisterone (which raises SHBG). What we see is that when norestisterone is given orally, it produces a far greater effect on SHBG, than when it is administered via an injection. And this is even when the doses of the injectable are 4x higher!

Here’s a chart, illustrating exactly what I’m talking about in this study, which I think suggests very strongly that injectable versions of drugs, when compared with the oral version, will have nowhere near as much of an effect on SHBG:

Of course, in this study, they’re looking at oral vs. injectable versions of a SHBG raising drug- but what we can take away from it is that SHBG interaction with oral compounds is far more pronounced than it is with injectables.

So lets take a small amount of Winstrol with our cycles, and free up some of those steroids we’re taking, right? Right!

Unless of course, we’re talking about women here…I was recently asked why I recommend that women use the injectable version of Winstrol over the oral. I was asked this question by someone, who I assumed had a female friend who was considering using Winstrol. I then realized I was totally incorrect- not about Winstrol, but about the reason behind the question. You see…I saw a picture of the man who had first asked me the question, and it’s readily apparent to me that he probably doesn’t actually know any women. But still, his question is valid and bears repeating and answering here.

I recommend that women avoid the oral version of this product for the same reason that men will find that it gives them an increased synergy and effectiveness in their cycles.

When SHBG is lowered in women, there is more free testosterone floating around. And as we’ve seen, the oral is going to affect SHBG exponentially more than the injectable will. When we lower SHBG too much in women, we see a strong positive correlation with hyperandrogenism (10 ), and hirsuitism (abnormal growth of body hair), as well In fact, non-SHBG-bound testosterone may actually be the defining characteristic for identifying hyperandrogenism in women. In addition, low SHBG contributes to menstrual irregularity.(11)

Finally, and (partially) anecdotally, we also see a greater incidence of clitoral enlargement and acne when the oral version of Winstrol is used by women instead of the injectable. The reasons for this are obvious- When we increase free testosterone by lowering SHBG, we increase the amount of testosterone which is able to be 5a-reduced to DHT. DHT is the primary culprit for steroid induced acne, and is also the hormone responsible for external genital enlargement. Clearly, this is why we see the increased level of clitoral hypertrophy as well as acne when oral Winstrol is used by women.

We can also see increased acne when men use Winstrol orally, but these effects are relatively minor when a 2mg/kg dose is being used to increase the effectiveness of other steroids in a cycle. This isn’t carte blanche to go using Winstrol for an extended period of time under the excuse that it’s increasing the overall effectiveness of the cycle. Stanozolol has some of the worst liver toxicity (hepatoxicity) of any oral steroid on a mg for mg basis. In addition, it’s deleterious effects on your lipid profile (Cholesterol) are also very pronounced, even at low doses- 6mgs/day of Stanozolol can lower HDL (good cholesterol)by 33% and raise LDL (bad cholesterol) by 29% (12 ).

So, hopefully, you’ve reached the end of this article and realized that Winstrol can be used in any cycle to increase the effectiveness of it, but that it must be used sparingly due to it’s possible hepatoxicity and lipid profile effecting properties. Still, when used in heavy testosterone-based profiles, at a dose that will cut your SHBG levels in half, it can increase you other steroids effectiveness quite a bit…but when maximal protein synthesis is wanted, you need to inject it.

There you go…the differences between oral and injectable Winstrol, and how you can use either form to maximize your gains! And yes, Lyle, you can drink Winny.

References:

1. Neural Androgen Receptor Regulation: effects of androgen and antiandrogen. Lu S, Simon NG, Wang Y, Hu S, J Neurobiol 1999 Dec; 41(4):505-12

2. Endocrinology. 1990 Feb;126(2):1229-34. Xu X, De Pergola G, Bjorntorp P

3. Endocrinology. 1984 Jun;114(6):2100-6.

4. Can J Vet Res. 2000 Oct;64(4):246-8.

5. J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22

6. MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK 1979 Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab 49:905–916

7. Agents Actions. 1994 Mar;41(1-2):37-43.

8. Sex Hormone Binding Globulin response to the Anabolic steroid: Stanozolol: Evidence for its suitability as a Biological Androgen Sensitivity test. J Clin Metab Endocrinol 68: 1195, 1989)

9. The Journal of Clinical Endocrinology & Metabolism Vol. 87,No. 2 530-539. An Effective Hormonal Male Contraceptive Using Testosterone Undecanoate with Oral or Injectable Norethisterone Preparations Axel Kamischke, Tanja Heuermann, Kathrin Krüger, Sigrid von Eckardstein, Ilka Schellschmidt, Alexander Rübig and Eberhard Nieschlag Institute of Reproductive Medicine of the University (A.K., T.H., K.K., S.V.E., E.N.), D-48129 Münster, Germany; and Schering AG (I.S., A.R.), D-13342 Berlin, Germany

10. Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism DC Cumming and SR Wall J. Clin. Endocrinol. Metab., Nov 1985; 61: 873 - 876.

11. Menstrual Irregularity in Women with Acromegaly G. A. Kaltsas, J. J. Mukherjee, P. J. Jenkins, M. A. Satta, N. Islam, J. P. Monson, G. M. Besser, and A. B. GrossmanJ. Clin. Endocrinol. Metab., Aug 1999; 84: 2731 – 2735

12. JAMA. 1989 Feb 24;261(Cool:1165-8

I've got it.................. :grin:

[I Declare War]

Lol, yeah that's the same one eh... you just did some chop chop on it. You need to leave the references in bro, makes it much more credible.

[Daz69]

Add this one to your database, Daz69...

Winstrol - Oral versus Injectable (More Different Than You Think!)

By Anthony Roberts

Yeh!! That's the full article I quoted from... :grin:

I've a load of stuff by Anthony Roberts, but He's had a bad press on here at times, I'd be interested to know what you think of his work.... ??

[I Declare War]

Add this one to your database, Daz69...

Winstrol - Oral versus Injectable (More Different Than You Think!)

By Anthony Roberts

That's the full article I quoted from... :grin:

I've a load of stuff by Anthony Roberts, but He's had a bad press on here at times, I'd be interested to know what you think of his work.... ??

He knows heaps... and he's got the right background to be able to interpret and make sense the studies he cites in his work. If he says something, it's gospel.

[Daz69]

Add this one to your database, Daz69...

Winstrol - Oral versus Injectable (More Different Than You Think!)

By Anthony Roberts

That's the full article I quoted from... :grin:

I've a load of stuff by Anthony Roberts, but He's had a bad press on here at times, I'd be interested to know what you think of his work.... ??

He knows heaps... and he's got the right background to be able to interpret and make sense the studies he cites in his work. If he says something, it's gospel.

Cheers...... I'll keep reading then..... :grin: