Notes on Drostanolone (Masteron)..

[Daz69]

Some science behind the mechanism of Drostanolone (Masteron):

Science cliff notes : Among the ligands for progesterone, glucocorticoid and androgen receptors, the 5alpha-reduction of a drug lead to a significant shift away from progesterone and glucocorticoid receptor binding and increased androgen receptor binding. At the same time it completely blocked aromatisation, yielding a much more androgen receptor specific drug. In the case of testosterone that was DHT, but DHT had problems with its use as an anabolic. It was quickly activated or deactivated by 3beta-HSD and 3alpha-HSD respectively (3a-androstanediol conversion is reversible, and apart from some GABA-ergic action, its mostly considered an inactive storage or clearance form of DHT, why 3b-androstanediol conversion is irreversible and it is a potent estrogen receptor beta activator). 3a-HSD was apparently very high in muscle making DHT very androgenic and not so anabolic. On top of that reduction of the 3-oxo group lead to more glucoronidation and faster excretion.

The 2-methyl group sterically hinders the 3-HSD enzymes and protects the 3-oxo group from reduction. As fate would have it, it also seemingly increased androgen receptor specificity (Ojasoo et al, 1995), making drostanolone probably the most specific androgen. It reduces overall binding to the AR, making it weaker than testosterone or DHT on a mg per mg basis, but because of its specificity doses can be increased incrementally without affecting any other receptors except the AR. The downside of blocking 3b-HSD function is the reduction of ERbeta agonism, and thus making it a greater risk for prostate hypertrophy. That is also the greatest concern with drostanolone.

If you didn't understand that, here are some basics:

Introducing Masteron

Drostanolone Propionate or Masteron is probably one of the most interesting steroids used by athletes. It is primarily for the treatment of breast cancer patients to inhibit estrogen production. 

Masteron is a derivative of dihydrotestosterone or DHT which restrains the conversion to estrogen through aromatization. It could be that its ability to inhibit estrogen from interacting with the aromatase enzyme or it blocks the receptor that binds the estrogen that causes this phenomena. Whatever the reason, because of its anti-estrogenic properties it blocks the conversion of free testosterone to estrogen through aromatization. This makes Masteron a common inclusion in a high anabolic cycle. Since compounds used in cycles to achieve mass gains and strengths have very potent testosterone content, Masteron is used to prevent the estrogenic side effects to take place. The side effects include bloating or water retention and gynecomastia. 

Even though Masteron inhibits testosterone conversion to estrogen it still has anabolic and androgenic properties, simply because it is still a derivative of DHT. While some think that there is low aromatization with Masteron it still has a significant androgenic side-effects that one should expect when using this steroid. 

Masteron come in two forms – Drostanolone Propionate and Drostanolone Enanthate. The recommended dosage for propionate, which is the more fast acting version, is around 50-150mg/ml. This version needs to be injected everyday. While the Enanthate version’s recommended dosage is at 200mg/ml. 

The anti-estrogenic properties make it a very effective cutting agent. When Masteron becomes part of their regular cycle it gives the muscles a more defined look. Muscle lines will be more distinct since it has lower water retention. When testosterone aromatase to estrogen there is a higher tendency to retain water that could cause bloating. Masteron will also draw out the water from between the muscles. Without the excess water weight and low body fat your muscles will be enhanced and you will see the finer details as your skin wraps tighter around them. Masteron could produce side effects such as decreased sex drive so to balance your body’s reactions to the steroid it is advised that you use stack it with other steroids.

When you introduce Masteron into your cycle make sure that you keep your body fat below 10% it is better if you already have a lean physique so that it will concentrate on its cutting functions and drawing out the excess water. 

While Masteron does not have that many side-effects it is not completely devoid of them. Some users may experience virilisation effects such as male pattern baldness to those who are prone to this condition, acne, and in some cases, aggression. 

Using Masteron

You can choose from the two forms of Masteron available as mentioned above – Masteron propionate and Masteron enanthate. Propionate is the fast acting form and the recommended dosage is between 350-500mg/week or 100mg/day every 2-3 days for men. For women the recommended dosage is 100/mg per week. The enanthate has a recommended dosage of 400-600mg/week. 

[Clueless]

Okay some questions on Mast E

 

How long does it take before kicks in?

 

Is it worth front loading?

 

On a cruise dose of test run at 400mg?

 

Have seen can be run at 200mg any one personally used at a lower dose??

[Realtalk]

600mg/week good

[atrollappears]

Okay some questions on Mast E

 

How long does it take before kicks in?

 

Is it worth front loading?

 

On a cruise dose of test run at 400mg?

 

Have seen can be run at 200mg any one personally used at a lower dose??

 

Same day, but maximal plasma concentrations about 4 half lifes..

 

Yes..

 

400mg test + Mast.. why bother..?

 

Yes..

[Hu Gh]

Why would you run such a beta cycle br0? Do you want to stay small and weak or actually make gains?

[Clueless]

Why would you run such a beta cycle br0? Do you want to stay small and weak or actually make gains?

Want to cruise for a while. Thought why not try some mast while doing it.

 

Also been a beta phaggot think estrogen playing with head, trying to clear that up.

[Hu Gh]

If I was you id just do proper cruise then. Test only and less than 400mg. Even 150mg pw is plenty and probably actually acheive what cruise sposed to do

[Realtalk]

Cruise dose test + 400mg Masteron enanthate isn't a cruise brO

[Tonkintechnique]

http://www.grapplehard.com/pedsinmma.php

 

 Its pretty surprising how many fighters have used Masteron.

[Clueless]

I was going to do Test 250mg, Mast 300-400.

[Hu Gh]

Yeah as realtalk said thats not cruise br0. Try test 150-250mg/week for 7 weeks+. Doesnt matter if you lose little bit size/strength youll get it back fast again once you blast. Sometimes your body just need a break so give it proper one not half assed cycle instead.

Know you prob won't listen though as you borderline gymrat disorder and probably read some shit on gh15 about cruising on 1g of gear. Gh15 shit spurce of info mostly and half the shit on there written by small weak ppl that probably dont even lift

[ngapuhi strong]

i know its bit off topic, but talking about cruise how long after stopping cycle would you have to go back on cycle before gains start to be lost with out pct

[HarryB]

i know its bit off topic, but talking about cruise how long after stopping cycle would you have to go back on cycle before gains start to be lost with out pct

 

 are gains going to be sustained with pct?

[ngapuhi strong]

 

i know its bit off topic, but talking about cruise how long after stopping cycle would you have to go back on cycle before gains start to be lost with out pct

 

 are gains going to be sustained with pct?

 

i dont know are they? i thought the idea of pct was to bring hormone levels back to norm with out losing gains

[atrollappears]

 

 

i know its bit off topic, but talking about cruise how long after stopping cycle would you have to go back on cycle before gains start to be lost with out pct

 

 are gains going to be sustained with pct?

 

i dont know are they? i thought the idea of pct was to bring hormone levels back to norm with out losing gains

 

 

Not really... Minimise losses is about all you can hope for with PCT and return hormonal balance hopefully back to pre-cycle levels if you are lucky...

[Clueless]

From what understand your body naturally can only hold a certain size of muscle mass.

ie Natty might be 85kg

If juice get up to 100 kg then pct etc etc, eventually will go back to natural set point ie 85kg

If cruise use a dose to maintain that 100kg mass

 

Correct me if wrong please

[Hu Gh]

Your body can hold more than what you prob think br0. You started juicing when you were small shit c*nt then got big on gear youll hold a lot more than you started with.

You still lose muscle/strength if you cruise too br0 unless you do a retarded cruise which isnt a cruise. Just dont lose as much as the no gear pct scenario as you dont have to deal with really low/no test for multiple weeks

[atrollappears]

From what understand your body naturally can only hold a certain size of muscle mass.

ie Natty might be 85kg

If juice get up to 100 kg then pct etc etc, eventually will go back to natural set point ie 85kg

If cruise use a dose to maintain that 100kg mass

 

Correct me if wrong please

 

In a roundabout way, probably yes, but its dependant on the intensity of your workouts plus the amount of food you are eating, plus years of commitment... Train & eat like shit, won't have the same genetic effects as optimum training and diet over many years... 

[Hu Gh]

Cliffs: train and eat like shit consistently over many years and youll have physique like daz's

[atrollappears]

Cliffs: train and eat like shit consistently over many years and youll have physique like daz's

:pfft:

[Hu Gh]

Haha nah daz your physique and your missus decent compared to most guys your age.

Anyway clueless basic model is your body just in equilibrium dependent on your genetics which are fixed and dependent also on variables of training diet and drugs. Gaining muscle is slowish process.