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Clen info - broscience or fact?

donz

By donz
in Steroids & prescription meds

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donz Senior member

donz

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So straight up as I've said I don't like clen, can't handle the sides but I do have a friend who is currently on it, now what I find interesting is hes from up north and I'm from central and down here the people I know who have used/use it all do for whatever reason 5 days on 2 days off yet up north from the friends I've talked to they all do 2 weeks on 2 weeks off, obviously more time to clear the receptors etc. I've researched this a bit before, back when I did try it and read a lot of talk about anti-histimines helping speed up the recovery time of your receptors ( I think HN-1? Off memory ) and was talking to my friend about it so basically being a top thinker he's gone out and brought some hay fever pills with cetirizine hcl in them in the hope he can run the clen for 3-4 weeks or more without a break. 

So ending that wall of text, does anyone have any solid info or fact that shows if this actually works or if it's just placebo or something else?

Once again I appreciate all your knowledge and loved answers XOX

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Dinahlady Senior member

Dinahlady

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Yeah i've heard of it, the "antihistamine" that is suggested is diphenhydramine which is a mildly controlled drug in nz. 

If It does work, I dont think just any antihistamine will work because of affecting a different receptor.  so if you wanna look up your mates meds to see if they are on there...: http://en.wikipedia.org/wiki/H1_antagonist

Not sure if theres any pharmacological reason why any of those other drugs there wouldn't work either. there could well be. if any of it is even legit. 

Most of these drugs are probably controlled or prescription, It would definitely not be legal to buy for use with clenbuterol and you would need to use deception or illegal trading to obtain them for use with clenbuterol. (Which I clearly don't condone)

I have no idea what the science is behind why a H1/cholinergic antagonist would effect the B2 adrenergic receptors. Could easily be legit but I dont have the answer to why. 

 

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donz Senior member

donz

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Sweet reply as usual Dinah~ I doubt anything I say will change his mind haha it was more for a told you so, suck-it and a personal reference to add to my tiny knowledge bank~ Will suss that link out during dinner :)

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Daz69 Senior member

Daz69

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As previously stated clen simply stimulates your beta-2 receptors. Clen is not approved by the FDA for use in humans so non anecdotal information for use in humans is like hen's teeth. With animal studies clen has shown to build muscle and increase strength. But as stated there is very little information proving that clen does the same with humans. Animals are quite different in their make up from us, including they have more beta-2 receptors than us.

Clen has a half life of between 7 to 9 hours. Most users will cycle the drug two weeks on two weeks off to clear out their receptors. The other way, which I prefer is to run ketotifen every 3rd week to restore receptor function. Some users of clen get bad cramps, taking a taurin supplement will most often counter this.

I don't believe any of the other antihistamines up-regulate beta-2 receptors. Stick to ketotifen fumarate. It's cheap and it works.

Ketotifen slows desensitization of Beta receptors (i.e. Upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly.

I don't believe any of the other antihistamines do this. People have speculated diphenhydramine could but I don't think there are any studies to back it up....

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Dinahlady Senior member

Dinahlady

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Ketotifen slows desensitization of Beta receptors (i.e. Upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly.

Sweet! 

Ketotifen is found in what - eye drops?? You eat that??

 

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pkgr33n Member

pkgr33n

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Yo DONZ!

Being a curious c*nt myself, I did some research a few months back when I was bored. I read things like clen basically lower the beta 2 receptors, and with the help of ketotifen it basically slows down the process of the receptors. So overall you are able to run clen for a longer period of time, say 3-4weeks, and you are able to use lower doses of clen and still receive the same effects/results. There was also this stuff on antihistamines etc I can’t remember lol. As well as stuff on about replacing ketotifen with Benadryl, but ketotifen has seem to be more effective.

One thing to consider is that ketotifen for some people can cause them to be real lazy/drowsy.

Pretty sure this theory was also backed up by scientific studies too; you’ll have to have a scope around.

Also maybe try out albuterol instead, I’ve never taken it personally, as there is no need for me atm, but I hear good things from a few friends who are on it, way less sides and works well. 

Not2sure if that helps but yeah haha

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pkgr33n Member

pkgr33n

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Haha sweet bro but the initial Q was for my mate - not at our gym BTW, like I said sides are too rough for me to wanna use it unless it was pre-comp or something Blum 3

Haha ohk, yeah man some dangerous stuff! I wouldn't go on it even sometime in the future lol

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Leeroid Veteran member

Leeroid

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Only contraindication I can think of is the drowsiness so best to take it before bed although I haven't noticed the effect at all. In studies, they have used up to 10mg everyday and no adverse side effects were noticed, which is good considering you only need 1-2mg a day. I've been taking it in the morning now and not drowsy at all.

 

I am prone to getting hayfever in the spring and I've noticed I haven't had any of the usual blocked or runny noses around this time of year. I guess an unintended benefit of the anti histamine, as it is used for allergy relief.

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rapz Senior member

rapz

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diphenhydramine  works fine imo, easily accesible OTC at any pharmacy, the product was Unisome sleep gels, think they cost something like $10-15 for like 10 x 50mg gels, another product in Panadol Night, never tried ketotifen, be worth trying the 2 and compare.

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Dinahlady Senior member

Dinahlady

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I am prone to getting hayfever in the spring and I've noticed I haven't had any of the usual blocked or runny noses around this time of year. I guess an unintended benefit of the anti histamine, as it is used for allergy relief.

That's just the sides of become more alpha as you get shredded. 

 

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