HCG dosing for PCT

[size8]

General protocol for HCG dosing after a basic Test C Cycle ,

HGC is real \:D/ and I would like to know frequency and I.U dosages that people have used.

Dont tell me to "Do your research" or "Google" etc, :evil: this is a part of it.

Please inform on your experiences / knowledge on the compound and its usage as part of a PCT cycle.

8.

[yeelang]

700IU week during cycle.

Used to blast the last 2 weeks before my cycle ended (with the above protocol), but i haven't found much difference compared to finishing HCG with my last shot of long ester AAS.

I haven't ever run HCG just at PCT. If I was to do that I would rather experiment blasting with a different compound

[size8]

700IU week during cycle.

Used to blast the last 2 weeks before my cycle ended (with the above protocol), but i haven't found much difference compared to finishing HCG with my last shot of long ester AAS.

I haven't ever run HCG just at PCT. If I was to do that I would rather experiment blasting with a different compound

Nice post, Thanks

Rich Piana did and interesting interview with Ric Drasin on the latest Rics corner. And he saying he never uses HCG on cycle at all. He only uses it as a PCT. The reasoning is due to the mix signal for both shut down and kick start of the nads etc. I found it very interesting to see his explainition. Check it out on YT.

Cheers.

8.

[soundsgood]

Rich Piana does not PCT

[I Declare War]

Rich Piana does not PCT

Rich Piana does Poly Methyl Meth Acrylate

[jimmybro1]

[soundsgood]

Respect

That was a great interview, Rich just went up 10 points in my book. Some good points raised. Wish he had stayed in the pct topic a bit longer.

I guess the real question is how many top level npc guys / Ifbb pros actually do cycle and pct these days

[Rxx]

Respect

That was a great interview, Rich just went up 10 points in my book. Some good points raised. Wish he had stayed in the pct topic a bit longer.

I guess the real question is how many top level npc guys / Ifbb pros actually do cycle and pct these days

All those vids with Rich and Ric are worth the watch. He does kind of go off topic a bit though, talks about alot more that the titles suggest. Pretty open and honest guy!

[jimmybro1]

It is definitely worth checking out his channel he is open about all topic's.

[Gain results]

2500iu each day for the first 8days of pct,along with 20mg nolva and 100mg clomid for 45days.......get bloods and test checked....off time generally 6-8 weeks .

[Daz69]

Hone used to post on here often, this is what he had to say on HCG:

I have used hCG for a number of years now, as part of PCT after cycle and while on cycle.

The most common side affect associated with hCG is gynecomastia. The concurrent intake of Nolvadex with hCG prevents gynecomastia, prevents/minimizes leydig cell desensitization and continues the stimulation of pituitary LH once hCG has been discontinued.

Human Chorionic Gonadotropin (hCG) is a peptide hormone that mimics the action of luteinizing hormone (LH). LH is the hormone that stimulates the testes to produce testosterone.

When you take AAS LH levels decline. The absence of an LH signal from the pituitary causes the testes to stop producing testosterone, this causes you're testes to shrink.

Based on studies with normal men using steroids, 100iu hCG administered everyday was enough to preserve full testicular function without causing desensitization/saturation associated with high doses of hCG.

A more convenient alternative to the above recommendation would be a thrice weekly shot of 250iu hCG, or possibly a twice weekly shot of 500iu. However, it is most desirable to adhere to a lower more frequent dose of hCG to mimic the body’s natural LH release and minimize estrogen conversion.

Another protocol is the blast method, this can be used if for some reason you haven't ran hCG on cycle.

This is often used towards the end of a cycle and/or the run up to PCT. Much higher doses are used, anywhere from 1000iu-5000iu. An example would be 2500iu - 5000iu shot 2-3 x wkly for 4wks.

A 6000iu shot increased testosterone by 50% but did not alter the T > E ratio. In fact some athletes have used hcg at 5000iu weekly while coming off cycle to successfully balance the T > E ratio.

I think it's worth pointing out that in clinical studies it was shown that a single 10000iu shot desensitized the leydig cells for 96hrs.

I am now using and advocating the protocol of 1000iu injected once weekly.

Here is the science behind this protocol.

An in vivo injection or an episode of LH secretion induced by GnRH, results in stimulation of the side-chain cleavage enzyme with the subsequent release of testosterone within 30-60 minutes of LH stimulation. The acute response to an injection of LH is dramatic in some species such as the rat and the ram but is much more attenuated in the human. This testosterone response lasts approximately 24-48 hours. If human chorionic gonadotrophin is used as an LH substitute, the kinetics of the initial stimulation are similar to LH but a second peak of testosterone secretion is evidence with hCG and occurs 48-72 hours after the initial injection. This biphasic pattern has been attributed to the observation that between 24 and 48 hours after an LH or hCG injection, the Leydig cells are refractory to further stimulation by either hormone. The second phase of testosterone secretion after hCG but not LH is associated with the longer half-life of hCG in comparison to LH. The hCG levels persist in the circulation and, following recovery from the refractoriness, testosterone levels increase. This observation has significant clinical importance since, in many men, a single weekly injection of hCG will suffice to maintain optimum testosterone responses rather than the frequent practice of giving injections of hCG two to three times per week.

The stimulation of leydig cells with large amounts of hCG rapidly reduces their number of receptors, this phenemenom is termed down-regulation. Although these changes decrease testosterone levels to just above diurnal maxima 24-48hrs after initial injection repeated stimulation does not yield the same results. A single injection of hCG is followed by a long steroidogenic response characterized by two phases of testosterone secretion. Studies show that this second phase which can last as long as 8 days can increase testosterone in plasma by 2.2 x above maximal diurnal secretion even though hCG is no longer present in plasma. The results indicate that hCG injections can be given every 6-7 days due to the prolonged steroidogenic response. It is advisable to start this protocol around week 2-3 in the cycle and continue till the start of PCT.

As stated hCG can cause gyno, this is probably due to to hCG's ability to incease the dynamics of the CYP450 enzyme, the aromatase enzyme is part of this family so it's possible to note a marked increase in aromatase activity, this should not prove to be a problem if you are already taking Nolva or an AI on cycle for estrogen management but it is something that you need to be aware of.

hCG use and the P450 cytochrome:

Firstly a little basic info on the P450 enzyme and why hCG use on cycle is extremely beneficial. The CYP450 (cytochrome P450) enzyme system is a key pathway for drug metabolism. Many lipophilic drugs must undergo biotransformation to more hydrophilic compounds to be excreted from the body.

The majority of drugs undergo phase I metabolism (e.g., oxidation, reduction) by CYP450 enzymes, this is especially indicative of anabolic androgenic steroids and endogenous steroid hormones. This is a good reason to use hCG. In laymans terms hCG increases the dynamics of CYP450 which in turn increases the rate at which drugs can be metabolized, which in turn increases protein dynamics.

Basically by the action of hCG on P450 dynamics it also increases pregnenolone which is the precursor for all other steroid hormones and has many benefits, one of which is that it serves to keep/restore a natural hormonal balance within this key pathway even if the HPTA is suppressed, it also has energizing, anti-stress benefits, elevates mood through the raising of NDMA activity and reduces excess Cortisol, so if we can increase this steroid hormone with the use of hCG, we should.

I thought HCG's action was on FSH, not LH..? hoping someone like Riccardo/Diabolic will clarify...