Eh My Bood Tests

[cruxis]

I have not taken any steroids (Yet). Even though I am posting in this section of the forum cuase it seems more appropriate here.

Weight 90Kg BF 15-18% Guess. Age 37. Male

Doc says I may have a pituitary disorder or Hypothyroidism. So has ordered Further tests and rule out a tumor on the pituitary gland. Passed the vision tests fine.

I am wondering if these results are the reason why when i try to bulk, I gain good muscle/strength. but also a bit of fat on my chest and stomach. When dieting I have to be spot on perfect, or I lose alot of muscle/strength.

Also I assume my renal function is normal for a male that trains with good protein intake? Liver is good too, Tests were taken about 1 hour after waking up.

Low White Blood Cells I dont know what could cuase this. I dont feel sick and not injured. Result of Training maybe?

Looking for advice on what questions I should ask the doctor(Endo) and what treatments to ask about. To get my levels into the normal range eg,prolactin. Not much chance of getting Testosterone at my age at there current level is there?

Reproductive Hormones.

Progesterone 3nmol/L

Prolactin 473 mIU/L (50 - 350) HH

17b Oestradiol <44 pmol/L (<160)

Testosterone 16.0 nmol/L (9.0 - 38.0)

betaHCG <5 IU/L (0-5)

Moderetly elevated prolactin, Contributory factors maybe stress,pregnacy,drugs,hypothyroidism or pitutitary disorder. Suggest evaluate in full clinical context.

Thyroid Function Tests

Free T4 21 pmol/L (10 - 24)

TSH 5.2 mIU/L (0.4 - 4.0) HH

Free T3 4.4 pmol/L (2.5 - 6.0)

Elevated TSH indicates possible borderline hypothyroidism.

Renal Function Tests

Sodium 142 mmol/L (135 - 145)

Potassium 4.5 mmol/L (3.5 - 5.2)

Urea 8.2 mmol/L (3.2 - 7.7) HH

Creatinine 110 umol/L (50 - 110)

eGFR 65 mL/min/1.73m2 L

The GFR range for young adult male is 87-167. From age 30 falls 1 mL/min/year

Liver Function Tests

Total Billirubin 8umol/L (2 - 20)

Alk. Phosphatase 78 U/L (30 - 150)

GGT: 17 U/L (10 - 50)

ALT 26 U/I (<41)

AST 22 U/L (10 - 50)

Total Protein 71 g/L (64 - 83)

Albumin 45g/L (35 - 50)

Serum Globulin 26g/L (18 - 36)

Liver seems to be in good health

Complete Blood Count

Haemoglobin 149g/L (130 -175)

PCV 0.44 Ratio (0.40 - 052)

MCV 95 fL (80 -99)

MCH 33pg (27 -33)

Platelets 204 (150 - 400)

WBC 3.9 (4.0 - 11) LL

Neutrophils 1.7 (1.9 - 7.5) LL

Lymphocytes 1.7 (1.0 - 4.0)

Monocytes 0.2 (0.2 - 1.0)

Eosinophils 0.2 (<0.6)

Basophils 0.0 (<0.3)

May indicate injury or illness.

[Grover]

Moderetly elevated prolactin, Contributory factors maybe stress,pregnacy,drugs,hypothyroidism or pitutitary disorder.

:clap: Its a miracle!

[musclenz]

I have not taken any steroids (Yet). Even though I am posting in this section of the forum cuase it seems more appropriate here.

Weight 90Kg BF 15-18% Guess. Age 37. Male

Doc says I may have a pituitary disorder or Hypothyroidism. So has ordered Further tests and rule out a tumor on the pituitary gland. Passed the vision tests fine.

I am wondering if these results are the reason why when i try to bulk, I gain good muscle/strength. but also a bit of fat on my chest and stomach. When dieting I have to be spot on perfect, or I lose alot of muscle/strength.

Also I assume my renal function is normal for a male that trains with good protein intake? Liver is good too, Tests were taken about 1 hour after waking up.

Low White Blood Cells I dont know what could cuase this. I dont feel sick and not injured. Result of Training maybe?

Looking for advice on what questions I should ask the doctor(Endo) and what treatments to ask about. To get my levels into the normal range eg,prolactin. Not much chance of getting Testosterone at my age at there current level is there?

Reproductive Hormones.

Progesterone 3nmol/L

Prolactin 473 mIU/L (50 - 350) HH

17b Oestradiol <44 pmol/L (<160)

Testosterone 16.0 nmol/L (9.0 - 38.0)

betaHCG <5 IU/L (0-5)

Moderetly elevated prolactin, Contributory factors maybe stress,pregnacy,drugs,hypothyroidism or pitutitary disorder. Suggest evaluate in full clinical context.

Thyroid Function Tests

Free T4 21 pmol/L (10 - 24)

TSH 5.2 mIU/L (0.4 - 4.0) HH

Free T3 4.4 pmol/L (2.5 - 6.0)

Elevated TSH indicates possible borderline hypothyroidism.

Renal Function Tests

Sodium 142 mmol/L (135 - 145)

Potassium 4.5 mmol/L (3.5 - 5.2)

Urea 8.2 mmol/L (3.2 - 7.7) HH

Creatinine 110 umol/L (50 - 110)

eGFR 65 mL/min/1.73m2 L

The GFR range for young adult male is 87-167. From age 30 falls 1 mL/min/year

Liver Function Tests

Total Billirubin 8umol/L (2 - 20)

Alk. Phosphatase 78 U/L (30 - 150)

GGT: 17 U/L (10 - 50)

ALT 26 U/I (<41)

AST 22 U/L (10 - 50)

Total Protein 71 g/L (64 - 83)

Albumin 45g/L (35 - 50)

Serum Globulin 26g/L (18 - 36)

Liver seems to be in good health

Complete Blood Count

Haemoglobin 149g/L (130 -175)

PCV 0.44 Ratio (0.40 - 052)

MCV 95 fL (80 -99)

MCH 33pg (27 -33)

Platelets 204 (150 - 400)

WBC 3.9 (4.0 - 11) LL

Neutrophils 1.7 (1.9 - 7.5) LL

Lymphocytes 1.7 (1.0 - 4.0)

Monocytes 0.2 (0.2 - 1.0)

Eosinophils 0.2 (<0.6)

Basophils 0.0 (<0.3)

May indicate injury or illness.

Providing your additional thyroid function tests show no abnormality, I would be looking at your Prolactin levels more than anything. Urea being the only other concern but is quite common in some people. Just watch your water intake is up there to avoid the onset of kidney stones as they are not pleasant Prolactin can inhibit sexual function in men & be a factor in erectil dysfunction. Prolactin works in the opposite of dopamine which causes sexual arrousal. So what you need if there is no pituitary of hypothalamus dysfunction or tumour, is a dopamine agonist like Dostinex or Bromocriptine. You could ask your Endo about this.

[Daz69]

Providing your additional thyroid function tests show no abnormality, I would be looking at your Prolactin levels more than anything. Urea being the only other concern but is quite common in some people. Just watch your water intake is up there to avoid the onset of kidney stones as they are not pleasant Prolactin can inhibit sexual function in men & be a factor in erectil dysfunction. Prolactin works in the opposite of dopamine which causes sexual arrousal. So what you need if there is no pituitary of hypothalamus dysfunction or tumour, is a dopamine agonist like Dostinex or Bromocriptine. You could ask your Endo about this.

From what I understand being Dopamine (DA) receptor agonists they have an inhibitory effect on PRL (prolactin) secretion, which seems to be under the control of the doperminergic pathway...

Does this lead to decrease in Dopamine levels in the long term and should sufficient levels of L-Tyrosine be included in the diet to account for this..?

On a side note: As well as acting on D2.... it also acts on 5-HT2A, and inhibits Glutamate release...

As 5-HT2A activation is a prerequisite to halluciogenic effects exerted by tryptamine psychedelics such as LSD, have users of Bromo or Caber experienced mild hallucinations..?

Can the inhibition of Glutamate effect long term memory or learning ability..?

[musclenz]

Providing your additional thyroid function tests show no abnormality, I would be looking at your Prolactin levels more than anything. Urea being the only other concern but is quite common in some people. Just watch your water intake is up there to avoid the onset of kidney stones as they are not pleasant Prolactin can inhibit sexual function in men & be a factor in erectil dysfunction. Prolactin works in the opposite of dopamine which causes sexual arrousal. So what you need if there is no pituitary of hypothalamus dysfunction or tumour, is a dopamine agonist like Dostinex or Bromocriptine. You could ask your Endo about this.

From what I understand being Dopamine (DA) receptor agonists they have an inhibitory effect on PRL (prolactin) secretion, which seems to be under the control of the doperminergic pathway...

Does this lead to decrease in Dopamine levels in the long term and should sufficient levels of L-Tyrosine be included in the diet to account for this..?

On a side note: As well as acting on D2.... it also acts on 5-HT2A, and inhibits Glutamate release...

As 5-HT2A activation is a prerequisite to halluciogenic effects exerted by tryptamine psychedelics such as LSD, have users of Bromo or Caber experienced mild hallucinations..?Can the inhibition of Glutamate effect long term memory or learning ability..?

Dont think so Big Cat :grin:

[Daz69]

Providing your additional thyroid function tests show no abnormality, I would be looking at your Prolactin levels more than anything. Urea being the only other concern but is quite common in some people. Just watch your water intake is up there to avoid the onset of kidney stones as they are not pleasant Prolactin can inhibit sexual function in men & be a factor in erectil dysfunction. Prolactin works in the opposite of dopamine which causes sexual arrousal. So what you need if there is no pituitary of hypothalamus dysfunction or tumour, is a dopamine agonist like Dostinex or Bromocriptine. You could ask your Endo about this.

From what I understand being Dopamine (DA) receptor agonists they have an inhibitory effect on PRL (prolactin) secretion, which seems to be under the control of the doperminergic pathway...

Does this lead to decrease in Dopamine levels in the long term and should sufficient levels of L-Tyrosine be included in the diet to account for this..?

On a side note: As well as acting on D2.... it also acts on 5-HT2A, and inhibits Glutamate release...

As 5-HT2A activation is a prerequisite to halluciogenic effects exerted by tryptamine psychedelics such as LSD, have users of Bromo or Caber experienced mild hallucinations..?Can the inhibition of Glutamate effect long term memory or learning ability..?

Dont think so Big Cat :grin:

I do think so Bigger Cat.... :grin:

The first evidence that hallucinogens act via the 5-HT2 receptor was the paper by Glennon et al. (1983)

LSD binds potently to the 5-HT2A (Hoyer, 1988; Lovenburg et al., 1993b)

All the phenethylamine halluciongens studied only bind to the 5-HT2A/B/C receptors (Adham et al., 1993; Erlander et al., 1993: Lovenberg et al., 1993a; Nelson et al., 1999; Pierce & Peroutka, 1989; Titeler et al., 1988; Zgombick et al., 1992)

This is just a short list of the early research into 5-HT2A receptor action for hallucinogenic activity

I'll PM you the papers I have if you like....

[Grover]

:notworthy:

Somebody does a lot of reading!

[musclenz]

From what I understand being Dopamine (DA) receptor agonists they have an inhibitory effect on PRL (prolactin) secretion, which seems to be under the control of the doperminergic pathway...

Does this lead to decrease in Dopamine levels in the long term and should sufficient levels of L-Tyrosine be included in the diet to account for this..?

On a side note: As well as acting on D2.... it also acts on 5-HT2A, and inhibits Glutamate release...

As 5-HT2A activation is a prerequisite to halluciogenic effects exerted by tryptamine psychedelics such as LSD, have users of Bromo or Caber experienced mild hallucinations..?Can the inhibition of Glutamate effect long term memory or learning ability..?

Dont think so Big Cat :grin:

I do think so Bigger Cat.... :grin:

The first evidence that hallucinogens act via the 5-HT2 receptor was the paper by Glennon et al. (1983)

LSD binds potently to the 5-HT2A (Hoyer, 1988; Lovenburg et al., 1993b)

All the phenethylamine halluciongens studied only bind to the 5-HT2A/B/C receptors (Adham et al., 1993; Erlander et al., 1993: Lovenberg et al., 1993a; Nelson et al., 1999; Pierce & Peroutka, 1989; Titeler et al., 1988; Zgombick et al., 1992)

This is just a short list of the early research into 5-HT2A receptor action for hallucinogenic activity

I'll PM you the papers I have if you like....

Its OK I found your thoughts to be true :grin:

At 5-HT2C receptors, lisuride, bromocriptine, pergolide, and cabergoline were efficacious (75-96%) agonists, apomorphine and terguride were antagonists, and piribedil was inactive. MDL100,907 and SB242,084, selective antagonists at 5-HT2A and 5-HT2C receptors, respectively, abolished these actions of pergolide, cabergoline, and bromocriptine. In conclusion, antiparkinson agents display markedly different patterns of agonist and antagonist properties at multiple 5-HT receptor subtypes. Although all show modest (agonist) activity at 5-HT1A sites, their contrasting actions at 5-HT2A and 5-HT2C sites may be of particular significance to their functional profiles in vivo.

Ref : http://www.neuroact.com/publications/an ... types.html

As I'm completely out of Big Pussy I'm tempted to restock on Caber :pfft: