Grapefruit juice

[farrout]

Grapefruit juice will increase the potency of most oral drugs including steroids here is the article :

James Maskalyk

Editorial Fellow, CMAJ

Grapefruit juice interacts with a number of medications. This unusual discovery was made serendipitously in 1989 during an experiment designed to test the effect of ethanol on a calcium-channel blocker.1 The observed response was later determined to be due to the grapefruit juice delivery vehicle rather than the alcohol. In the past decade, the list of drug interactions with grapefruit juice has expanded to include several classes of medication, precipitating a recent advisory from Health Canada.2

The interaction: As little as 250 mL of grapefruit juice can change the metabolism of some drugs.3 This drug–food interaction occurs because of a common pathway involving a specific isoform of cytochrome P450 — CYP3A4 — present in both the liver and the intestinal wall. Studies suggest that grapefruit juice exerts its effect primarily at the level of the intestine.4

After ingestion, a substrate contained in the grapefruit binds to the intestinal isoenzyme, impairing first-pass metabolism directly and causing a sustained decrease in CYP3A4 protein expression.5 Within 4 hours of ingestion, a reduction in the effective CYP3A4 concentration occurs, with effects lasting up to 24 hours.6 The net result is inhibition of drug metabolism in the intestine and increased oral bioavailability. Because of the prolonged response, separating the intake of the drug and the juice does not prevent interference.

Individuals express CYP3A4 in different proportions, those with the highest intestinal concentration being most susceptible to grapefruit juice–drug interactions.5 An effect is seen with the whole fruit as well as its juice, so caution should be exercised with both.7 The precise chemical compound in grapefruit that causes the interaction has not been identified. There is no similar reaction with orange juice, although there is some suspicion that "sour oranges" such as the Seville variety, may have some effect.8 A recent study, however, that tested the known interference of grapefruit juice with cyclosporine showed no similar effect with Seville oranges.9

There is some interest in the potential therapeutic benefit of adding grapefruit juice to a drug regimen to increase oral bioavailability.3 The limitation is the individual variation in patient response. However, if the chemical that causes grapefruit's CYP3A4 inhibition is elucidated, there may be an opportunity to modulate that pathway in a controlled fashion.

What to do: Much of the data obtained on grapefruit juice–drug interactions involved measuring serum drug concentrations in small numbers of healthy volunteers. Because of the limited data and only occasional case reports,10 it is difficult to quantify the clinical significance for individual patients. One may assume that the interaction occurs primarily with oral medicines, and only with those that share the CYP3A4 metabolism pathway, with the consequence being increased oral bioavailability, higher serum drug concentrations and associated adverse effects.

Physicians should review medication lists often, with the goal of warning patients about adverse interactions. A list of medicines with which patients should not consume grapefruit is provided in Table 1.3,11,12 In the case of several medications that share the CYP3A4 metabolism pathway, but for which a clinical effect has not been elucidated or is theoretical, patients should be advised to consume grapefruit cautiously and be monitored for toxicity.

Has anyone tried this?

I've started today with Proviron & Dbol.

[I Declare War]

Don't drink it when using Cialis or Viagra. lol

[Terrymundo]

I've heard the myth grapefruit juice has the reverse effect. for example (for the ladies) you may increase your risk of pregnancy if grapefruit juice is consumed whilst properly using oral birth control, even doctors say its a nono. But when its put into practice with AAS maybe the story is different.

[Chemo]

Theres a Super Human Radio article that covers how to increase the availability of oral steroids.

Grapefruit Juice, and fatty foods help.

even to a point where you can take test -e orally and still get 70% of the hormone. Meeeaaaaaaaaaaan.

http://www.superhumanradio.com/631-oral ... ility.html

Grapefruit, coconut cream, oxandrolone smoothie ... Do it

[Daz69]

Don't drink it when using Cialis or Viagra. lol

Why..? :shock:

[I Declare War]

Don't drink it when using Cialis or Viagra. lol

Why..? :shock:

I read on the info sheet when I got some Cialis once, that you shouldn't... I was thinking that Grapefruit juice may make Cialis "too effective", as that's what grapefruit juice does to a lot of drugs... but I've just done some googling and come across this:

https://www.riverpharmacy.ca/faq/does-g ... pple-juice

With other Men's Health medications like Sildenafil Citrate (Viagra, Silagra) and Tadalafil (Cialis, Tadacip), grapefruit juice inhibits the body's absorption of the medication. The substances in the juice that do this are called furanocoumarins. They activate one of the body's naturally-produced drug efflux mechanisms, known as P-glycoprotein, located in the intestinal tract. When grapefruit juice interacts with P-glycoprotein, the result is an increased likelihood that certain drugs will be stopped from entering the bloodstream. Viagra and Cialis are therefore less effective when grapefruit juice is present in the body.

[Riccardo]

I've heard the myth grapefruit juice has the reverse effect. for example (for the ladies) you may increase your risk of pregnancy if grapefruit juice is consumed whilst properly using oral birth control, even doctors say its a nono. But when its put into practice with AAS maybe the story is different.

Nope it inhibits metabolism therefore higher blood concentrations. Docs recommend against it for women when taking OC as it can lead to side effects such as clotting problems.

[severe]

Probably best to squeeze grapefruit juice yourself, as shelf versions are usually diluted. So, you may need to increase drink size to cover 250mls of 100% juice.

Tried it when on Dbol, but not sure of its worth as it couldve been placebo, based on reading similar articles.

[train hard]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

[DANIEL8]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

when creatine just came out i was wearing nappies

:shock: :shock: :shock:

[train hard]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

when creatine just came out i was wearing nappies

:shock: :shock: :shock:

i took it in the late nintys i think it had been around a few years before that im still a young fulla lol

[I Declare War]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

when creatine just came out i was wearing nappies

:shock: :shock: :shock:

i took it in the late nintys i think it had been around a few years before that im still a young fulla lol

:shock: bro, gotta realise we're the old fuckers around here now. hahaha

[Daz69]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

I thought I'd read somewhere that Orange Juice cancels or limits the effectiveness of Creatine..?

[train hard]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

I thought I'd read somewhere that Orange Juice cancels or limits the effectiveness of Creatine..?

there is particular enzymes in sour fruit or grapefruit that helps carry supps or drugs through the intestinal wall and reach the blood stream intact apparently oranges don,t have the same effect or could have an opposite effect sort of says that in the study the OP posted as well

[farrout]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

It was grape juice, first read about in a Muscle Media 2000 article written by the late Dan Duchaine in early 1995. The price of EAS Phosphagen - the world's first commercial creatine monohydrate powder - was CRAZY :grin:

[Flex]

i remember when creatine just came out and everyone used to preach that you take it with grapefruit juice to enhance absorption worked for me but maybe water would have been just as effective i don,t know

It was dark grape juice not grapefruit juice only because of the carbs in it.

Grapefruit contains naringin and the extract is often used in OTC fat burners. It extends the half life of certain drugs/medications and ingredients, and is often used with stimulants to extend the stimulant/fat burning effect.

You can use it with a lot of things but extending the half life isn't always too good for your health. If you use it with Cialis/Viagra then you'll probably have a boner for days hence why it may not be so good for you.