Clen downtime and antihistamines?

[maassive]

I've read a few times that in your off week from clen you can/should take a certain type of antihistamine to help revitalize the B2 receptors.

Can anyone clarify this further including relevant studies if known. Specifically would like to know what kinds of antihistamines one should take.

chur

[Riccardo]

Personally I don't see how any anti-histamine would work to upregulate beta-2 receptors, I don't know what science people use to justify it and haven't found anything to suggest that anti-histamines protect against receptor down regulation or upregulate beta-2 receptors. However some people swear by benadryl.

The only thing I think anti-histamines would do is make you drowsy and reduce anxiety associated with stimulant use. I know that glucocorticoids have a protective effect on receptor downregulation (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC185177/) and funnily enough, Histamine, increases the release of glucocorticoids from the adrenal glands (http://joe.endocrinology-journals.org/c ... /371.short). So if anything, drugs that block the effect of histamine (anti histamines) are more likely to worsen receptor downregulation one would think?

The best thing for for receptor down regulation is time off, in fact, the normal recycling of receptors into the cell and preventing them from further stimulation helps them resensitize. (http://molpharm.aspetjournals.org/conte ... /666.short). Take from it what you will but I think the best option is just to ensure you have a protocol with plenty of down time. 2 weeks on 2 weeks off or something similar.

[musclenz]

Personally I don't see how any anti-histamine would work to upregulate beta-2 receptors, I don't know what science people use to justify it and haven't found anything to suggest that anti-histamines protect against receptor down regulation or upregulate beta-2 receptors. However some people swear by benadryl.

The only thing I think anti-histamines would do is make you drowsy and reduce anxiety associated with stimulant use. I know that glucocorticoids have a protective effect on receptor downregulation (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC185177/) and funnily enough, Histamine, increases the release of glucocorticoids from the adrenal glands (http://joe.endocrinology-journals.org/c ... /371.short). So if anything, drugs that block the effect of histamine (anti histamines) are more likely to worsen receptor downregulation one would think?

The best thing for for receptor down regulation is time off, in fact, the normal recycling of receptors into the cell and preventing them from further stimulation helps them resensitize. (http://molpharm.aspetjournals.org/conte ... /666.short). Take from it what you will but I think the best option is just to ensure you have a protocol with plenty of down time. 2 weeks on 2 weeks off or something similar.

This is the arguement for downregulation & using anti- hist to upregulate the Beta2s although the jury is still out I believe as to how effective this protocol is. I have taken this pot from ISteroids because it contains the standard proceedure. Be interested to know how it works for those have used anti-hs for this purpose.

A strategy to allow you to use clen for more than 2 weeks at a time.

Benadryl slows desensitization of Beta receptors (i.e. upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly.

This will allow you to use clen for much longer and it´ll still have the same effects.

Also, since Benadryl is an anti-histamine, and histamines have a direct effect on beta-adrenoreceptors (not just Beta-2´s but all of them), using an anti-histamine will have a direct effect on reducing beta-receptor stimulation, and thus upregulating your beta-receptors.

Normally clen stops working so well after 2 weeks due to Beta receptor down-regulation. As Clen will raise your body temperature, you´ll want to know your body temperature, upon rising, for the week before you start taking your clen, and then monitor it (again, as soon as you wake up) throughout your clen regimen. When it returns to the level it was at before you began taking the clen, you´ll need to start taking your Benadryl or Ketotifen, as the decrease in Body Temperature back to original levels indicates the thermogenic effect is beginning to decline.

Clenbuterol can also cause a downregulation in testicular androgen receptors and in pulmonary, cardiac and central nervous system beta-adrenergic receptors possibly making steroids less effective (if there is androgen receptor downregulation elsewhere as well, then it´s highly probable) while you are on clen; but definitely making clen less effective as time goes on and you keep taking it. To counteract this, you can take some ketotifen or benadryl every 3rd or 4th week that you remain on clen. It's an anti-histamine, so it'll make you drowsy (which is why it's taken before bedtime).

Basically, the way this works is to reduce beta-2 receptor activity, and restore receptor function

So the method is taking Benadryl, at around 50-100mgs/night before bed (every 3rd week or so, for that week). To elaborate on the above, Beta receptors are embedded in the cell´s outer phospholipid membrane. The stability of the membrane has a lot to do with the proper function of the receptors. Methylation of the phospholipids is stimulated by the binding of beta agonists to their receptors. Methylated phospholipids are foreign to the body, and when the body recognizes them as foreign, it breaks them down with phospholipase A2. This changes the structure of the outer membrane which results in desensitization of the beta receptors. On the other hand, agents that inhibit phospholipase A2 slow desensitization.

Cationic ampiphylic drugs are known for their ability to inhibit phospholipase A2. Benadryl (diphenhydramine) is a cationic ampiphylic drug.