Tren experience?

[WANABJAKD]

There is not a lot of information on this & as I'm not an endocrinologist I cant say but from what I have read prolactin secretion seems to be under the control of the dopaminergic neuronal system, so it is thought that somehow progesterone interacts with this system to increase prolactin. Dopaminergic agonists like Caber and Bromo inhibit prolactin secretion, whereas a large number of drugs, including antidepressants and antipsychotics, stimulate prolactin secretion. this is often the cause of libido & ED issues in AD users & drug addicts like meth where there is an initial sexual high followed by decreasing libido as the drug becomes established more permanently in the body.

Also anabolic steroids seem increase the metabolic breakdown of both dopamine and serotonin in the human body. Low serotonin levels have been implicated in anxiety, aggression, violent behavior, and impulsiveness, as well as depression. This may be a the cause of "roid rage". The decrease in dopamine may very well be responsible for an increase in prolactin in steroid users. This, coupled with excess estrogen from aromatizable androgens could be a cause of gynecomastia.

is there anything that can metabolize progesterone apart from letro?

You mean inhibit progesterone. Im not too sure. Good question. There is some links I recall about Hcg & Progesterone. Hcg is used to stimulate the placenta in pregnant women to bring on birth. I'll have to check. Typically you control estrogen not progesterone which is really only a problem if using progestins like Tren.

well i read that it lowers the progesterone levels so i just assumed it binds and metabolizes it just like estrogen :?: ...this was just out of interest than anything.

i decided to begin running prami just to be on the safe side with prl. i feel its already climbed up pretty quick so i dont wanna wake up with milk sweats i noticed that my sex drive had kinda dulled down after taking a huge spike when beginning the tren and that its much easier to sleep. is it safe to say using prami to lower PRL will bring my sex drive back up but also my insomnia?

[bulking]

Prami is horrible on sleeping patterns.

I tried it when using NPP.

Id wake up every 2 hrs wide awake, had to pack it in after 10 days.

Start low and work up

[WANABJAKD]

Prami is horrible on sleeping patterns.

I tried it when using NPP.

Id wake up every 2 hrs wide awake, had to pack it in after 10 days.

Start low and work up

work up to what dose ? im just running .5mg ED

[bulking]

You should start at around 0.2 then ramp up to 0.5 and then assess how its going. If you just jumped on 0.5 and havnt seen sides id wonder if yours is dosed correctly.....alternately you may just have a high tolerance to it. I ramped up to 0.5 and felt like a zombie first time i took tht dose.

Heres a copy paste from somewhere:

Prolactin suppression using Pramipexole

For Prevention: when you are taking something that can cause prolactin issues or when you just want to lower prolactin, for the benefits of lowering prolactin.

0.125 (1/8) to 0.5mg (1/2) per day should generally be sufficient for most users. With prevention slow escalation should not be an issue

For Treatment: When you have ongoing prolactin issues, Gynecomastia flare, or are attempting to regress gynecomastia tissues (ductal, lobular and central gland mass).

0.375 up (3/8) to 1mg should generally be sufficient for most users. Most people will not need over 0.5mg. If you do, then SLOWLY escalate the dose. You still should start at 0.25mg and slowly work up. see bottom for exceptions

doses should be taken in the evening, 2-4 hours prior to bed. For the very low doses, an hour is probably fine. if it keeps you up, take it earlier. If it makes you sleepy "too soon" then take closer to bed. a good number of people will notice niether. taking with last meal of the day may be ideal for a lot of people.

Now for you people that want high end dosing benefits, which are not prolactin suppression. This is a lot more complex, and generally requires a VERY slow progression in dosing to acheive. Clinicals increased the dose by 0.125 every 3-5 days. there will typicallly be side effects for people at various point along the progression. IT IS EXTREMELY IMPORTANT THAT YOU BE AWARE OF THESE BEFORE YOU LAUNCH INTO HIGH END DOSING.

EDIT- IMPORTANT NOTE-

for those that do not have dopaminergic sides, other than "waking up from sleep"-- which is caused by the drop in pramipexole in the plasma and the subsequent surge of dopamine release from the tissues in which they were suppressed, JUMPING the dose up more quickly will generally alleviate this. this is for those for whom interupted sleep is the primary and pretty much only side effect. this applies to treatment and high end dosing (at least until sleep interution abates).

[WANABJAKD]

i did notice a couple things though it was only my first dose. the halflife isnt longer than a day but i will wait to see what happens over the next few days.

[Pete_S]

Doesn't dostinex control prolactin?

[bulking]

Yes dostinex does although from memory its not as effective.

Main reason its not used more is that alot of people use liquid 'research' chems and dostinex (sold as cabergoline) isnt very effective in liquid form.

[musclenz]

Yes dostinex does although from memory its not as effective.

Main reason its not used more is that alot of people use liquid 'research' chems and dostinex (sold as cabergoline) isnt very effective in liquid form.

Yes the liquid form out of the US has not got good reviews. If you can source Pharma Dostinex Tabs or a good Generic version they are good & have no sleep disruption sides like Prami.