Clenbuterol longterm adverse effects

[Ryno33]

I know all the short term but I am wanting to know the long term effects.

Ive done my homework but all I can find is that it MAY have adverse effects to the heart in the long run due to strengthening of the muscles surrounding it.

Can anyone confirm this etc? and experiences?

I'm thinking about using it in the future not exceeding 120mcg but I don't to ruin the ticker lol.

Cheers

[Ryno33]

bump?

[musclenz]

I believe you would be hard pressed to find a clinical study that would back up your observation. I have not heard of a direct correlation between Clenbuterol & Heart Disease. However, it may stem from that fact that Clen is not actually a steroid nor a hormone, it is a repartitioning agent & is closely related to the catachcholamines adrenaline & noradredaline. It is actually a Beta 2 agonist. It acts on beta 2 receptors which are widely distributed in muscle cells. As you know adrenaline is a CNS stimulant & like any excessive use of this drug or any CNS Stim, it could have adverse effects on the heart. Its not a drug that the body can tolerate for any length of time & has diminishing effects when used long term. The body adapts to it quite readily.

[nate225]

There is a study I cited many years ago linking clenbuterol to death of cardiac cells. Cant remember the details but search pubmed or a similar database.

[musclenz]

There is a study I cited many years ago linking clenbuterol to death of cardiac cells. Cant remember the details but search pubmed or a similar database.

I might be a Rat but my Physiology is different :pfft:

[nate225]

There is a study I cited many years ago linking clenbuterol to death of cardiac cells. Cant remember the details but search pubmed or a similar database.

I might be a Rat but my Physiology is different :pfft:

A lean rat? :pfft:

[tomsammce]

There is a study I cited many years ago linking clenbuterol to death of cardiac cells. Cant remember the details but search pubmed or a similar database.

I might be a Rat but my Physiology is different :pfft:

A lean rat? :pfft:

rat or mouse? lol

[nate225]

I haven't got access to databases at the mo but these might be of interest:

Rats http://cardiovascres.oxfordjournals.org ... 1/115.full

Horses http://www.ncbi.nlm.nih.gov/pubmed/11932573

Peeps http://www.elitefitness.com/forum/anabo ... 62264.html

[Outkast]

it will make you gay

[musclenz]

I haven't got access to databases at the mo but these might be of interest:

Rats http://cardiovascres.oxfordjournals.org ... 1/115.full

Horses http://www.ncbi.nlm.nih.gov/pubmed/11932573

Peeps http://www.elitefitness.com/forum/anabo ... 62264.html

For every Clinical Rat Study there is a countering one :grin:

From http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract

Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes.

Petrou M, Wynne DG, Boheler KR, Yacoub MH.

Royal Brompton National Heart and Lung Institute, London, UK.

BACKGROUND: Skeletal muscle assistance of the circulation for patients in end-stage heart failure requires electrical training of the latissimus dorsi flap to produce fatigue resistance. This process of electrical transformation and the development of postmobilization atrophy results in a profound loss in peak power generated. The beta 2-adrenoceptor agonist Clenbuterol was used to investigate its potential to selectively induce skeletal muscle hypertrophy, particularly the latissimus dorsi muscle (LDM), independent of adverse effects on cardiac muscle. METHODS AND RESULTS: Forty-one male Sprague-Dawley rats were divided into four groups and used in this study. Clenbuterol 2 micrograms.g body wt-1.d-1 was administered subcutaneously for a period of either 5 weeks (group A) or 2 weeks (group A1). Groups B and B1 (controls) were injected with 0.5 mL normal saline once daily. At the end of the experimental period, all rats were weighed and terminally anesthetized for removal of the left LDM, left gastrocnemius-plantaris-soleus (GPS) muscles, and heart. The results showed that the increase in body weight did not differ significantly between the Clenbuterol-treated and control groups (P > .5). The ratio of LDM to tibial length (hypertrophic index) for groups A and A1 was significantly greater than controls (P < .01), which represented a 20% to 29% increase. The hypertrophy was more pronounced for hindlimb skeletal muscle (21% to 35% for GPS), and the effects of this relatively high dose of Clenbuterol on the heart were less marked (18% to 20% hypertrophy). RNA analyses indicate that ventricles of Clenbuterol-treated rats express elevated levels of mRNA to atrial natriuretic factor without a concomitant increase in skeletal alpha-actin and beta-myosin heavy chain, consistent with a "physiological" form of cardiac hypertrophy. CONCLUSIONS: Clenbuterol induces significant hypertrophy of the LDM associated with specific changes in cardiac gene expression.PMID: 7586459 [PubMed - indexed for MEDLINE]