quick question on SD...

[BodySculpt]

of which there may not be an answer..

Ive tried a few different AAS etc, but the one that stoood out was SD, for some reason i "popped" on this stuff, the results were very different to any other, the traps started to pop out and muscle bellies started to round out if you know what I mean... i was shaping out in all the right areas. this was my first cycle btw of which may not have any relevance. oh and i lost all gains post cycle as i knew nothing of PCT at the time.

has anyone had a similar experience on SD or the like?

it was deffinately hard on the liver at 40mg tho..

[musclenz]

Was a typical designer steroid like 1AD & Methyl-1 Test based on the Masteron compound Drostanalone. Like most PH's it has the potential to shut you down, put pressure on the liver & cause estrogen issues.

[KRS1]

40mg :shock:

I've run it as a kick start to two cycles at 20mg/day.

Great strength and weight gains, no water/estro whatsoever.

I took milk thistle with it and my liver was fine, yes I had blood tests.

Superdrol shouldn't cause estrogen issues as it can't aromatize.

I think I read once that superdrol has a great ability to increase glycogen/intracellular water, more so that other AAS.

Better than Dbol imo, wish I had more.

[Hennie]

40mg :shock:

I've run it as a kick start to two cycles at 20mg/day.

Great strength and weight gains, no water/estro whatsoever.

I took milk thistle with it and my liver was fine, yes I had blood tests.

Superdrol shouldn't cause estrogen issues as it can't aromatize.

I think I read once that superdrol has a great ability to increase glycogen/intracellular water, more so that other AAS.

Better than Dbol imo, wish I had more.

Gyno was an issue with SD on a few threads....

http://forum.bodybuilding.com/showthrea ... =118479071

[musclenz]

40mg :shock:

I've run it as a kick start to two cycles at 20mg/day.

Great strength and weight gains, no water/estro whatsoever.

I took milk thistle with it and my liver was fine, yes I had blood tests.

Superdrol shouldn't cause estrogen issues as it can't aromatize.

I think I read once that superdrol has a great ability to increase glycogen/intracellular water, more so that other AAS.

Better than Dbol imo, wish I had more.

Superdrol is a progestin not unlike Deca. It upregulates the PR (progesterone receptor) . Nolvadex does not work for SD estro problems. You need an AI like Femara & sometimes a Dopamine agonist like carbergoline

[KRS1]

40mg :shock:

I've run it as a kick start to two cycles at 20mg/day.

Great strength and weight gains, no water/estro whatsoever.

I took milk thistle with it and my liver was fine, yes I had blood tests.

Superdrol shouldn't cause estrogen issues as it can't aromatize.

I think I read once that superdrol has a great ability to increase glycogen/intracellular water, more so that other AAS.

Better than Dbol imo, wish I had more.

Superdrol is a progestin not unlike Deca. It upregulates the PR (progesterone receptor) . Nolvadex does not work for SD estro problems. You need an AI like Femara & sometimes a Dopamine agonist like carbergoline

Im not sure it is a progestin, nothing about it's structure suggests it might be.

I think the article linked by Hennie describes how it happens pretty well. Have you noticed how all these cases of gyno occured after the cycle.

People have reported the same problems with other designer steroids, pheraplex, epistane etc.

I think the main reason for all the gyno cases reported with these products stems from the fact that the vast majority of users had no idea about proper PCT.

SD was sold OTC in many countries to hundreds of thousands of kids/people who were very ignorant of what they were doing to their bodies.

If you make something that powerful available to kids OTC at your local supplement shop of course you are going to run into problems.

I don't believe superdrol is any more inherantly dangerous than any of the common AAS. But just like you wouldn't think a box of matches is dangerous, in the hands of a child (who doesn't understand what could happen if they play around with it) those matches are very dangerous.

[musclenz]

40mg :shock:

I've run it as a kick start to two cycles at 20mg/day.

Great strength and weight gains, no water/estro whatsoever.

I took milk thistle with it and my liver was fine, yes I had blood tests.

Superdrol shouldn't cause estrogen issues as it can't aromatize.

I think I read once that superdrol has a great ability to increase glycogen/intracellular water, more so that other AAS.

Better than Dbol imo, wish I had more.

Superdrol is a progestin not unlike Deca. It upregulates the PR (progesterone receptor) . Nolvadex does not work for SD estro problems. You need an AI like Femara & sometimes a Dopamine agonist like carbergoline

Im not sure it is a progestin, nothing about it's structure suggests it might be.

I think the article linked by Hennie describes how it happens pretty well. Have you noticed how all these cases of gyno occured after the cycle.

People have reported the same problems with other designer steroids, pheraplex, epistane etc.

I think the main reason for all the gyno cases reported with these products stems from the fact that the vast majority of users had no idea about proper PCT.

SD was sold OTC in many countries to hundreds of thousands of kids/people who were very ignorant of what they were doing to their bodies.

If you make something that powerful available to kids OTC at your local supplement shop of course you are going to run into problems.

I don't believe superdrol is any more inherantly dangerous than any of the common AAS. But just like you wouldn't think a box of matches is dangerous, in the hands of a child (who doesn't understand what could happen if they play around with it) those matches are very dangerous.

You may well be right on SD, KRS1. I remember the debate continues on how some of these PH's react in the body. There was also debate on whether anadrol was a progestin. I'm a bit out of touch with SD as its a relatively "old" drug as you know.

I dug this interesting article up on Steroidology which goes into detail how it converts to DHT & binds to the AR. In the old days we thought it bound to the PgR but the results are similar in the end as to the increased levels of prolactin that remain elevated after the cycle stops & confirming your observation on its rebound effect. Sorry to be so uninformed. I should keep up with the play more

"Anyone who knows anything about chemical structures will see that superdrol is not a progestin, and shouldnt cause prolactin like side effects.

The problem is everyone is different and eveyone has different amounts of progestin receptors, wich can cause worse sides in some users than others, one guy can use deca and get no bloat, another with the same dose will get bloat and gyno, because of this one reason alone. Now Beastsrol or superdrol is in itself not that androgenic, and as its structure suggests its not that different to other dht based steroids, now an action takes place that explains how it works... its doesnt act like a typical androgenic, but acts a little like oxymetholone, in that it doesnt show any real affinity for the 5AR enzyme, so you get weaker affinty for the androgen receptor than dht, but you get stronger androgenic effects as the enzyme 3beta hydroxysteroid dehydrogenase has little effect on the androgen affinity of superdrol.

The problem is this same enzyme 3beta hydroxysteroid dehydrogenase, is used in the conversion of many metaobiles in the body, Superdrol produces a lot of metabolites that dont get bound by the androgen receptor like we just saw, it cant aromatize, so it doesnt bind to the estrogen receptor, but it circulates, as its also a di methyl, it is very biovailable so a lot of the product circulates in the blood, and these extra metabolites dont bind specificly...not in the way they should.. so i will explain in a detailed way then make it much easier to understand.

Prolactin is normaly caused by progestins, but can also be caused by dht, how?

For example, it is currently understood that when testosterone enters the cell cytoplasm it is subsequently converted to the more "active" androgen, dihydrotestosterone, DHT, by reduction at the 5alpha position, This is normal. Dihydrotestosterone is then either bound to a cytoplasmic "receptor" protein Rc, or is further metabolized to either 5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol ,DIOL. The binding of DHT to its cytoplasmic receptor protein results in translocation of the steroid-receptor complex into the nucleus where presumably the complex dissociates and DHT exerts its androgenic effects. The transport of DHT to the nucleus can also result from the conversion of testosterone to DHT by nuclear membrane-bound 5alpha-reductase. Prolactin augmentation of DHT effects is envisioned as resulting from interaction of prolactin with its receptor, which due to the large size of the prolactin molecule is probably located in or on the plasma membrane.

Because superdrol is androgenic, but lacks the ability to show affinity via 5ar, it circulates, and this causes the large amounts of androgens to look for a transporter, so that it can bind to the androgen recptor, so it uses prolactin wich has a high affinity to cytoplasmic receptor protein, allowing the androgens, testosterone, to be carried and allowing them to convert to dht, only problem is prolactin hormone or luteotropic hormone is synthesised and secreted by sex binding lactotrope cells in the adenohypophysis (anterior pituitary gland, And this gland now produces more prolactin to help deal with the large amount of testosterone circulating that hasnt bound to the estrogen of androgen receptor, Part of the reason why superdol is so anabolic, So instead of binding to the androgen receptors in the scalp and the prostrate it converts to dht through this unique process, using prolactin to enter the cytoplasmic receptror protein, and allowing it to convert to dht and then bind to the androgen receptors in the muscle, causing its distinct hardening effects, it still cant bind to the scalp or prostrate via 5ar as the form of dht it has converted too doesnt allow for that affinity.

So more prolactin is produced to allow for the superdol to find a receptor ,this excess prolactin triggers a process that fills the breast with milk via a process called lactogenesis, in men however it causes a distinct enlargment of the mammary gland and can even cause a man to lactate.

If superdrol had better binding to the androgen receptor via 5AR then this problem would be prevented, the other thing is that prolactin production can remain elevated for months after a cycle has finished, and once the androgen has been removed, ( the cycle is over) the cytoplasmic receptor proteins have nothing to do other than to allow the prolactin to proceed with its hormonal action within the body, causing the male mammary gland to enlarge ready to produce milk... Hence the REBOUND gyno, this is why proper pct is needed for superdrol, and the use of something to prevent prolactin."

[BodySculpt]

nice one guys. interesting read MuscleNZ.