DNP

[KRS1]

I've noticed a few threads lately about cutting/weight loss/thermogenics. Why does noone mention DNP?

From my research and personal experience its a lot safer than most people believe and results are great.

I ran 200mg/day for 10days and dropped 3kg without any change to my diet.

Only side i noticed was increased body heat and sweating.

Anyone else got experience or thoughts about this drug?

[nate225]

As I mentioned somewhere earlier I have used DNP as an uncoupler in biochemistry situations. It certainly does the business in this regards and will shred fat off you.

HOWEVER it has been the cause of a number of fatalities (not in NZL as far as I'm aware) due to the fact it is not a rate limited effect. Most other products have an enzyme or some step in the pathway that limits the amount they can exert their effect on the human body. My understanding is that DNP does not, and as such too much will cause the core temperature to raise through the roof, which can lead to death or organ damage (or at the least getting your ass packed with ice in order to stop you cooking!).

I'm unsure of how close the effective dose is to the potentially fatal dose, however from memory it's a fairly fine line, hence people ending up in trouble.

IMHO I'd suggest there are safer methods to use.

[samoan_muscle]

200mg is a pretty low dose anyway...how much do you weigh?

3 kilos of fat or water?

[nate225]

Wikipedia info here, but I'm guessing it's of little use (and potentially dodgy info) for BBing purposes: http://en.wikipedia.org/wiki/2,4-Dinitrophenol

[KRS1]

200mg is a pretty low dose anyway...how much do you weigh?

3 kilos of fat or water?

At the time I dropped from 92-89. I'm sure most of the weight was fat. final weight was at day 13 after glycogen supercompensation.

In the 1920s or 30s thousands of people were prescribed DNP, some at up to a gram a day for many months. Only a couple of deaths and I think in those cases it was proven the patients were taking a much higher dose than recommended.

I don't think any deaths have occured in people using under 1g a day, and when it's effective at 200-400mg/day I think the danger has been way over estimated.

It's certainly not a drug you want to try and push the boundrys with but for effective, jitter free fat loss, its something I would suggest people at least look into.

Animal studies have even shown significant anti-aging benefits

[nate225]

200mg is a pretty low dose anyway...how much do you weigh?

3 kilos of fat or water?

At the time I dropped from 92-89. I'm sure most of the weight was fat. final weight was at day 13 after glycogen supercompensation.

In the 1920s or 30s thousands of people were prescribed DNP, some at up to a gram a day for many months. Only a couple of deaths and I think in those cases it was proven the patients were taking a much higher dose than recommended.

I don't think any deaths have occured in people using under 1g a day, and when it's effective at 200-400mg/day I think the danger has been way over estimated.

It's certainly not a drug you want to try and push the boundrys with but for effective, jitter free fat loss, its something I would suggest people at least look into.

Animal studies have even shown significant anti-aging benefits

A product best left to experienced and educated users I would suggest? SM / KRS1 your thoughts?

It would be rare for me to say this, but in this case I'd suggest the prescription alternatives (ECA, Clenbuterol & other beta stimulants) are probably safer options than this less restricted product? (although ephedra / ma huang products seem to have caught a bad rap in US press in recent years).

[KRS1]

As with anything definately do your research before using.

If anyone wants to learn more about DNP, search for posts by a guy called "Conciliator" on the Elitefitness and professionalmuscle boards (probably other boards too). This guy seems to be the leading internet authority on DNP and really knows his stuff.

One good thing about DNP that nate elluded to is that DNP is not illegal to posess or consume, only illegal to sell for intended consumption.

All drugs have side effects and can be painted in a bad light. i read some where that Middlemore hospital sees around 10 people a week with severe acute liver failure from paracetamol overdose. I believe any drug can be used responsibly, except perhaps methamphetamine.

[musclenz]

Never used DNP & its one compound that I have no great desire to try. I have been around a few good threads on US boards which proved to be a bit of an eye opener in that if used at relatively low doses around 200mg ed it does work very effectively perhaps more than any other fat burning drug. Its probably got a bit of a bad rap from many opponents of its use as a pharmaceutical. I think its often the unstable nature of the beast & handling issues because you cant get the yellow shit off anything it touches. The sides other than the risk of internal overheating include severe diarrhea, insomnia, emotional & irritable & long term there could be links to cancer because it releases free radicals. as Nate eludes, there surely is many safer fat burning options than putting an explosive & foreign substance into your body to shed a few kgs. You could achieve the same result with a bit of additional cardio & cleaning up your diet. People are just looking for a quick fix. Why wouldn't you be prepared to alter your diet to achieve a result. But good on those users that have tried it. As stated you can overdose on paracetamol which puts OTC drugs into a different perspective. By the way, Medsafe list Dinitrophenols as a prescription drug so it is not legal to use it in NZ without a prescription & I doubt that many doctors would write you one for DNP

[KRS1]

Actually DNP reduces free radicles. By uncoupling the proton gradient across the mitochondrial membrane it reduces the action in the electron transport chain further down stream in ATP production. It is in the electron transport chain that alot of reactive oxygen species (ROS or free radicals) are produced.

DNPs ability to reduce free radical production in the mitochondria is one of the proposed mechanisms for its effect of extended life expectancy seen in nematodes and mice in several studies.

Bit of regurgitated info there, pretty sure I got it right.

DNP has not been linked to cancer and has only been assumed carcinogenic because almost all other phenolic compounds are.

Im not trying to pimp DNP, Im just a little suprised not to see it mentioned more often in this country.

[musclenz]

Actually DNP reduces free radicles. By uncoupling the proton gradient across the mitochondrial membrane it reduces the action in the electron transport chain further down stream in ATP production. It is in the electron transport chain that alot of reactive oxygen species (ROS or free radicals) are produced.

DNPs ability to reduce free radical production in the mitochondria is one of the proposed mechanisms for its effect of extended life expectancy seen in nematodes and mice in several studies.

Bit of regurgitated info there, pretty sure I got it right.

DNP has not been linked to cancer and has only been assumed carcinogenic because almost all other phenolic compounds are.

Im not trying to pimp DNP, Im just a little suprised not to see it mentioned more often in this country.

Very nice post KRS1. I too was just parroting what I could remember from discussions over the years. I had not seen the article on mitochondrial uncoupling http://ouroboros.wordpress.com/tag/mice/ but found this which I assume you are referring to. I also though DNP was damaging to DNA but that seemed to be supported in the study. It sure is an interesting compound. Maybe there is a place for it

[severe]

In the 1920s or 30s thousands of people were prescribed DNP, some at up to a gram a day for many months.

Asbestos was safe then too. There are worse things out there, but

it will be a case of let the user beware...

[KRS1]

I've never seen that particular article but it does explain exactly what i was talking about.

They showed lowered blood glucose, lower triglycerides, and lower insulin. Most importantly, DNP treated mice showed an extended lifespan

Asbestos never had these health benefits.

In a few months when the weather is cooler i will have to do some more experimenting with this drug.