Femara, Arimidex & Aromasin - using AI's in NZ

[musclenz]

In response to the questions on other threads about using AI's, I thought it might be beneficial to get a discussion going on it. Comments appreciated.

In NZ we are somewhat limited by the available AI's more than the best ones. There are basically 3 different AI's used in PCT or for on cycle estrogen control. These are Letrozole (Femara), Exemestane (Aromasin) & Anastrozole (Arimidex). All are used for the treatment of breast cancer in varying stages.

AI's are classed into 2 types:

Type 1- suicidal or non competative inhibitors - Aromasin being this type

Type 2- competative inhibitors - Arimidex & Femara

The difference is in the way they bind or inhibit in aromatase. Type 2 are not regarded as quite as effective because they can release the emzyne again for further activity where type 1 does not.

Femara is generally regarded as the strongest AI & best for gyno lump issues. Arimidex is regarded as best suited for use on cycle because it only does in about 60% of the estrogen & aromasin is best suited to use on PCT. However, if you could get Aromasin in NZ (Even difficult on a script) it would appear from the way it acts in men to be the most suitable.

"When it comes to this comparison its more about type of estrogen suppression as opposed to "strength". Arimidex is a VERY potent sulfatase inhibitor, which inhibits estrone. It is a moderately strong aromatase inhibitor (weak as compared to aromasin or letrozole). This is fine for women with breast cancer who produce percentage wise very high levels of estrone (the weak estrogen), which can be converted to estradiol (the strong estrogen) via aromatase.

For men this is generally not very good, especially for men on TRT since sulfatase inhibitors have very little effect on exogenous testosterone. Actually its generally not a good thing since it nearly completely eliminates estrone, while still allowing estradiol. If you have a choice as a man, you want estrone (weak estrogen) with near total elimination of estradiol (strong). Aromasin does inhibit sulfatase, though to a lesser extent than the competitive inhibitors (dex and letro). They are both potent aromatase inhibitors and highly suppress estradiol. Since exogenous test converts to estradiol via aromatase, aromasin is much better suited. " edited Macro AFB.

Because Femara Generics from India have been readily available in NZ until recently, we have adopted the use of this AI into our regimes but it is probably not the best choice in a perfect (black market) world

I would be interested to have input from those that have used these AI's or others (AIFM, Chrysin, ATD, 6-OXO, etc) as to how efective they were & what side effects were apparent. Please post up if you can help.

[aidangro]

I used ATD after a pro-hormone cycle, it put my Anxiety levels though the roof so i stop after 3 days and still have it sitting in my supp cabinet, sorry this is not real info for ya, but if theres anyone else out there with a anxiety disorder i would stay well away from this one.

[musclenz]

I used ATD after a pro-hormone cycle, it put my Anxiety levels though the roof so i stop after 3 days and still have it sitting in my supp cabinet, sorry this is not real info for ya, but if theres anyone else out there with a anxiety disorder i would stay well away from this one.

Never heard of it causing anxiety but there was one school of thought that reckoned it competed for the AR along with testosterone which seemed counter productive. Its one I dont know much about but is similar in action to NovedexXT & Rebound XT from memory.

[mollswan]

i get aromasin & adex from a pharmacist m8 of mine at the cost price its still exspensive would h8 2 c the black market price on them. :shock:

[musclenz]

i get aromasin & adex from a pharmacist m8 of mine at the cost price its still exspensive would h8 2 c the black market price on them. :shock:

SERMS are ok price but AI's like dex can get right up there

[mollswan]

was shocked at the adex price 1st off then aromasins got anatha $40 on top of that.yikes!

[mr natural]

i think a mths worth of adex from a pharmacy is about $200 right?

[mollswan]

yea bro just under.