Help serious..

[Loochi]

[attachment=0]loochi.jpg[/attachment]

hey loochi

my girlfriend your ex girlfriend left this picture of you for me to see

and yea gh gut is pretty common

internal organs expanding pushing the stomach out

LOL dude, tell her to stop hating on me... It's over between us...

Thanks for the input dude! Appreciate it.

[Loochi]

Thanks for the input you guys.

Whether the effects are bad or not, a noob shouldn't even consider... He doesn't even gym really and always has excuse for leg day.

"Working late tonight" Lol.

[trainharder]

and yea gh gut is pretty common

internal organs expanding pushing the stomach out

This is a myth. There is no scientific evidence to prove anything about organs pushing the stomach out lol

People who are wasting away who use GH are on a much higher dosage than bodybuilders and I don't see them with huge guts...?

so are you saying growth hormone does not cause organs to grow.

it only affects muscle tissue not any other part of the body.

most articles ive read seems to say that most organs grow as well including the heart etc.the few guys i know who have taken gh all have distended bellies still rock hard though

i guess some people believed the world was flat for a long time and didnt want to believe otherwise.

[mr natural]

i think its a combination of things, lots of food,water retention in the digestive tract, hgh ,insulin ect...not just hgh alone

[trainharder]

yep i agree with you totally mr natural

and also believe that maybe some individuals wont get the same bad side affects that others might. that goes with any substance

im pretty sure it contributes to distended bellies in some people and not others. even on the same diet,doseage and other drugs taken.

[bulking]

Systemic administration of GH stimulates longitudinal bone growth and skeletal muscle growth, whereas IGF-I treatment preferentially increases the size of lymphoid tissues (spleen and thymus) and kidney (58). Growth hormone causes more robust longitudinal bone growth than IGF-I in animals, and the effects of these factors may be additive (59–61);

58. Guler HP, Zapf J, Scheiwiller E, Froesch ER. 1988. Recombinant human insulinlike growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc. Natl. Acad. Sci. USA 85:4889–93

59. Clark R, Carlsson L, Mortensen D, Cronin M. 1994. Additive effects on body growth of insulin-like growth factor-I and growth hormone in hypophysectomized rats. Endocrinol. Metab. 1:49–54

60. Clark R, Mortensen D, Carlsson L. 1995. Insulin-like growth factor-I and growth hormone (GH) have distinct and overlapping effects in GH-deficient rats. Endocrine 3:297–304

61. Fielder PJ, Mortensen DL, Mallet P, Carlsson B, Baxter RC, Clark RG. 1996. Differential long-term effects of insulinlike growth factor-I (IGF-I) growth hormone (GH), and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats. Endocrinology 137:1913–20

I believe(theory) That Igf-1lr3 abuse is mainly(edit) to blame for the distended gut.

But in the way a hobbiest bodybuilder would use it I don't think it is likely to create a sustained increase in size. Increased proliferation and decreased apoptosis are the mechanisms of IGF-1. Remove IGF-1 and the rate of apoptosis will resume so the organ should decrease in size.

Chronic administration of IGF-1 can induce straight-up organ growth and this would not be positive

[BainTrain]

so are you saying growth hormone does not cause organs to grow.

where did i say that?

[trainharder]

so does growth hormone only make muscle and bones grow nothing else

im just curious on that

and also growth hormone causes the liver to excrete high doses of insulin.

theres many studies on that

i should cut and paste some.

[bulking]

Who said it only makes muscle and bones grow?

The pancreas produces Insulin not the liver. If you have a study saying the liver produces it id be surprised.

You mean Igf-1 from the liver im sure. They are differant.

The levels of igf that are secreted due to GH usage are tiny in comparison to the doses of igf-1 lr3 that bodybuilders use.

[trainharder]

Effects of growth hormone on the tissues of the body can generally be described as anabolic (building up). Like most other protein hormones, GH acts by interacting with a specific receptor on the surface of cells.

Increased height during childhood is the most widely known effect of GH. Height appears to be stimulated by at least two mechanisms:

Because polypeptide hormones are not fat-soluble, they cannot penetrate sarcolemma. Thus, GH exerts some of its effects by binding to receptors on target cells, where it activates a second messenger.[vague][2] Through this mechanism GH directly stimulates division and multiplication of chondrocytes of cartilage.

GH also stimulates production of insulin-like growth factor 1 (IGF-1, formerly known as somatomedin C), a hormone homologous to proinsulin.[12] The liver is a major target organ of GH for this process and is the principal site of IGF-1 production. IGF-1 has growth-stimulating effects on a wide variety of tissues. Additional IGF-1 is generated within target tissues, making it apparently both an endocrine and an autocrine/paracrine hormone. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth.

im not disagreeing with you guys im sure you are very knowledgable

but i find it hard to agree that big doses of gh doesnt affect internal organs causing the stomach to distend .

i still think gh causes all organs to grow as well as bone and muscle

if you can show me something studies that show otherwise il change my mind.