YK11 SARMs are starting to get interesting!

[Chemo]

http://www.ergo-log.com/yk11-sarm-myostatin-inhibitor-in-one.html

Some cool progress on the SARMs front. 
I don't know how much Sarm use goes on here, but worth a look.

I've used ostarine and felt it was not worth the money you pay for it, but that's as far as its gone.
I've seen there are a few more SARMs, stronger that ostarine, but with that comes a cost.
Still waiting for something that overtakes gear!

Anyone experienced some of the newer sarms? LGD 4033 etc





 

[yeelang]

Not SARMS but MK-677 I wouldn't be surprised if it blows up in the recreational scene

 

I'll try and get a hold of it and test it

[atrollappears]

Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression.

Kanno Y1, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y.

Author information

 

Abstract

The myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist, (17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), as well as by dihydrotestosterone (DHT). YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. These results suggest that the induction of Fst is important for the anabolic effect of YK11.