IGF-1 LR3

[Leeroid]

Any guys out there that have had experience with this peptide? Worth it?

[9762291220]

its quite expensive for a peptide isnt it?

[nate225]

Apparently very good, however my concern (echoed by one researcher) is around response of cardiac muscle, which as you know is similar to skeletal muscle. Rumour is that it was used heavily by a particular group of bodyuilders with tremendous gains over short term period (12-18 months), but a number of these people suffered cardiac issues. No validation of this but worth looking into - afterall living is a pre-requisite to competing! :-D

[Leeroid]

Cheers Nate, you're a wealth of information

[GyzzBrah]

Nate, what are your thoughts on cancer linked with GH and peptide use etc? Because if gh causes cells to divide, would that increase the probabality of cancer? And also, hasn't Igf (the type made in the body) been linked to tumors / aging etc? For example animal protein increasing igf putting ppl at risk in some study.

[yeelang]

I'm personally getting more into this myself, I read an interesting article promoting short acting IGF-1 over lr3 due to it having localized effects with lower side effects. It was all just hypothiszed. Short acting is also much cheaper

 

I think in the future there will be a lot more people doing daily pins into training areas, just because of how much more research there is growth promoting compounds that need to be taken locally (PEG-MGF, AA, PGE-2, TNF etc) and how much better they are with overall sides.

 

If you could take half the AAS but make the same gains using localized factors it's a no brainer in terms of side effects.

 

[Leeroid]

Would you mind linking the article?

[nate225]

Yeah I definitely think HGH / IGF-1 etc would be a means to a quick end if you had pre-existing Ca, or even be a huge risk if you were high Ca risk (i.e. family history of bowel Ca etc). Haven't seen any research on this but then I haven't looked, and worth noting the use of BBers / athletes tends to be supraphysiological level compared to "ethical" treatment levels.

MGF / PegMGF is probably a safer option? Stronger than IGF1 (apparently) and MGF almost all local due to IM shots that are active for minutes only, PegMGF more systemic & I'd like to hear more. MGF is pretty cheap, PegMGF seems to be a lot more pricey.

[yeelang]

Having trouble finding the article, I'll keep looking

The issue with IGF-1 is the difference between local and systemic (floating around your blood). It seems that what you want is localized for any benefit in terms of muscle and systemic can't do this because it needs to bind to something (I forget) that's produced in the liver. This chain of thought is that IM injects of IGF are kind of hit or miss because of how easily it can leave and enter the blood stream without actually binding/stimulating. It's better to take GH because GH causes elevations in localized IGF-1.

The other school of thought is this it's awesome and you need to try it before you listen to all the science.

MGF is kind of the same, I think PEG-MGF works out to be only about 20% better, the key here is that it's used to help satellite cells proliferate so it's best taken pre/post/intra, likewise IGF-1 helps satellite cells differentiate so that's better taken slightly after. The other key factor with MGF is that it needs to have the proper sequence. There's around 3 different sequences all labeled MGF but only one that seems to have the best reults

 

I’ll post when I find it

 

 

[atrollappears]

Local autocrine/paracrine IGF-1 is what is important for muscle growth. In other words IGF-1 made in muscle & used there, not the systemic IGF-1 circulating from the liver is what contributes to muscle growth.

 

GH that acts in muscle promotes Stat5a/b signaling.

 

Stat5a/b signaling acts to promote BOTH IGF-1 expression and Androgen receptor expression in skeletal muscle.

 

The enhanced Androgen Receptor promote muscle growth when androgens bind.

 

Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor, Peter Klover, September 2009 The FASEB Journal vol. 23 no. 9 3140-3148

http://www.fasebj.org/content/23/9/3140.abstract

 

 

 

[Leeroid]

Daz so you would recommend IGF DES over LR3 and MGF over PEG MGF?

[atrollappears]

Daz so you would recommend IGF DES over LR3 and MGF over PEG MGF?

I think its too expensive, if you can get it..!! 

I thought there were only 2 legit FDA approved sources of IGF-1, and everything else is shite.. 

I've had MGF-PEG micro dosing recommended for injuries, but as far as growth, I think your better off with Test, hGH, and maybe insulin... 

Trying to get anything legit here in NZ is probably a waste of time anyway...

I'll ask a M8'...

[atrollappears]

Apparently there is an Austrailian company selling legit IGF-1 receptor grade

GroPep:

https://gropep.com/product_families/igf-i-family/products/human-igf-i-receptor-grade--33

https://gropep.com/media/BAhbBlsHOgZmSSI+MjAxNC8wMi8xOS8wM18xNV8zMl83NzNfSHVtYW5fSUdGX0lfUkdfc3BlY2lmaWNhdGlvbnMucGRmBjoGRVQ/Human%20IGF-I%20(RG)%20specifications.pdf