Thyroid hormone resistance

[Leeroid]

http://psychology.wikia.com/wiki/Thyroid_hormone_resistance

 

"Some forms of hormone resistance affect the conversion of T4 thyroid hormone to T3 and result in insufficient hormone reaching bodily tissues the at the cellular level. This type of conversion malfunction is not always detectable by blood tests which tell us how much hormone is circulating in the blood not what is reaching the tissues.

 

The result is that these patients improve or even recover completely while their blood tests may indicate they are taking too much thyroid hormone. Since they must take more thyroid hormone than others, the result is an excess of thyroid hormone floating around in the blood stream, however what reaches the tissues is usually far less, in fact a normal amount. This shocks doctors who do not understand thyroid hormone resistance. Such doctors are under a mistaken belief that if the blood tests show thyrotoxicity (too much thyroid hormone) then it must be true, even though their patients cannot recover or feel well without this high dose. Doctors like Refetoff, Lowe, Berndtson, Wilson and Papernick have come to discover, that to bring their patients health and free them from their terrible symptoms, they must prescribe these large doses. Interestingly, aside from the blood test results, thyroid hormone resistance patients do not experience the symptoms of thyrotoxicity such as diahhreah, hives, hair loss, heart palpitations and nervousness and in fact do experience the symptoms of hypothyroidism if they are not medicated with these high doses of T3.

 

Dr. Refetoff has studied people who needed 1000mcg of T4 and 500mcg of T3 before feeling well. These are doses that would kill a normal person and yet for those with thyroid hormone resistance, living without these supraphysiologic doses feels like death."

 

For those who are not familiar with T3, a normal person produces about 10-25mcgs a day naturally and for cutting purposes, doses of 50-100mcgs a day is normal for bodybuilders. If you go up to 200mcgs/day that's considered pretty crazy and that's from bodybuilders who usually take multiple times the recommended dosages.  

 

I was researching T3 yesterday and came across this interesting article. Apparently it can be quite common, as much as 3% of the female population are estimated to have some kind of thyroid hormone resistance. 

 

I was wondering if there could be a similar sort of resistance to testosterone which could be either genetic or developed through the use of exogenous testosterone?

[donz]

Nice info bro thanks! I really have not looked into taking it as I was, I guess scared off by people saying if you take it theres a chance of ruining your thyroid and then needing it all the time ( no idea of legitimacy to those claims ) I do however know I wish I had the genetic condition my best mate has "over active thyroid" cos when it comes time for him to cut for comps or just summer.. shred city, it's nuts! 

Have you run any T3 cycles before? I hear also it's better done with clen ( ugh ) - just curious to your results or anyone elses if they just ran T3 alone with whatever gear they were on etc