Testostereone Plasma Levels Between Injections

[tomsammce]

Did not read... But boring now when ppl quote link these studies...

Dunno bout rest of u guys, but me i cbf.

[Riccardo]

Hmmmm I must have made a mistake Daz, I can't find the thing I was referring to but I do remember it also. I forget now but basically it said arimidex's mechanism of action was to stop the conversion of androstenedione to estrone and didn't have as much of an effect on the conversion of testosterone to estradiol.

The key here is that the production of estradiol is different in females than what it is in guys with large amounts of testosterone in their body. In women the majority of estradiol is synthesized via androstenedione which is converted to estrone and then to estradiol which is why arimidex is so effective in lowering estradiol in women. Women do not convert much androstenedione to testosterone in their ovaries as there is no expression of 17-Beta-HSD-3 the enzyme which is hugely important for this step in men.

In men however large amounts of exogenous testosterone is converted directly into estradiol which is why I think arimidex may not be as effective in lowering estradiol in men. This was my thinking in my message to Daz. Will have to dig up these papers and have a look, I may have missed something important here, don't go throwing out your adex :pfft:

[I Declare War]

Hmmmm I must have made a mistake Daz, I can't find the thing I was referring to but I do remember it also. I forget now but basically it said arimidex's mechanism of action was to stop the conversion of androstenedione to estrone and didn't have as much of an effect on the conversion of testosterone to estradiol.

The key here is that the production of estradiol is different in females than what it is in guys with large amounts of testosterone in their body. In women the majority of estradiol is synthesized via androstenedione which is converted to estrone and then to estradiol which is why arimidex is so effective in lowering estradiol in women. Women do not convert much androstenedione to testosterone in their ovaries as there is no expression of 17-Beta-HSD-3 the enzyme which is hugely important for this step in men.

In men however large amounts of exogenous testosterone is converted directly into estradiol which is why I think arimidex may not be as effective in lowering estradiol in men. This was my thinking in my message to Daz. Will have to dig up these papers and have a look, I may have missed something important here, don't go throwing out your adex :pfft:

Arrghh! *digs through his rubbish bin*

[musclenz]

Hmmmm I must have made a mistake Daz, I can't find the thing I was referring to but I do remember it also. I forget now but basically it said arimidex's mechanism of action was to stop the conversion of androstenedione to estrone and didn't have as much of an effect on the conversion of testosterone to estradiol.

The key here is that the production of estradiol is different in females than what it is in guys with large amounts of testosterone in their body. In women the majority of estradiol is synthesized via androstenedione which is converted to estrone and then to estradiol which is why arimidex is so effective in lowering estradiol in women. Women do not convert much androstenedione to testosterone in their ovaries as there is no expression of 17-Beta-HSD-3 the enzyme which is hugely important for this step in men.

In men however large amounts of exogenous testosterone is converted directly into estradiol which is why I think arimidex may not be as effective in lowering estradiol in men. This was my thinking in my message to Daz. Will have to dig up these papers and have a look, I may have missed something important here, don't go throwing out your adex :pfft:

This arguement was placed on some overseas boards a few years ago & there was some supporting evidence for using Aromasin in favour of Arimidex because of the nature of how Aromasin works as a suicide inhibitor & effectively kills the aromatase enzyme vs how arimidex just binds to it & can be eventually released. I believe it had something to do with promoting the use of aromasin which is a more expensive drug. I agree though that most studies done are in relation to how E1,E2,E3 work in females & do not take into account males using high doses of exogenous testosterone. However, it does not negate the fact that Adex is still effective at reducing serum E2 in males as is Letrozole & Aromasin. The key in using them is to not overdose unless yr pre contest where its "Better to look good, than feel good"

[Riccardo]

Ahhh so it all comes down to money lol. Going off topic here but musclenz what are your thoughts on using a taper + arimidex for a pct instead of nolva/clomid/hcg?

[musclenz]

Ahhh so it all comes down to money lol. Going off topic here but musclenz what are your thoughts on using a taper + arimidex for a pct instead of nolva/clomid/hcg?

Well bro the taper was the way the old pros went until anti-Es were established. Its quite nice to taper off on an oral like Dbol, Proviron or Stanz for 3 weeks then hit yr SERM or AI for the PCT. THey call this a "soft landing" in contrast to a "crash" :pfft: Its also possible just to do a very gradual taper usually on an oral then just come off. You may need to use a Test Booster like ZMA or Trib. then be looking for natty signs to show in libido & general strength etc

[severe]

Vitex inhibits the action of male androgens (sex hormones). The name "Chaste tree" came from it’s use by monks to decrease libido. Vitex effects prolactin, the hormone responsible for making breast milk in women (although men have prolactin hormone, too). In very small doses, (120mg), prolactin may be increased in men. In higher doses, prolactin is decreased in both men and women.

Maybe I am missing something here, but even if it inhibits the actions of hormones, it wouldn't eliminate them from the blood. It should still be present in the test.

Like an AI, it inhibits the estrogen from working but blood tests would still show high estrogen.

Or am I way off wth this vitex thing? Doesn't add up.

[cruxis]

Update.

Bloods are in. Looking good. Seems it was NOT the vitex most likely just the drop off in levels between injections as the previous test was 3 days past injection. This latest one is 1 day after. Or just other factors like SBHG increase, Lab Testing accuracy of high levels, Things musclenz mentioned. Anyways I real feel good, Sexual function good, Strength is clearly up. Recovery outstanding. Shoulder is better for not doing any overhead pressing for a week.

Week 5

First Cycle.

37Yrs Male. 96Kg up from 88kg. 2x250mg Test Ethanate week. Adex 0.5ED

Results.

Plasma Testosterone 44.3nmol/L (8.0- 38.0)

Prolactin 224 miu/L (50-350)

17b Oestradiol <67pmol/L (<160)

Red Blood Cell Count 151 (130-175)

Rest of bloods pretty much unchanged from precycle baseline.

Seems adex has continued to lower 17b Oestradiol down and will adjust dose to 0.5mg eod. Although I felt my nipples when crushing/rubbing them using the preacher curl machine. :shifty:

Anyways I had enough of the weekly blood testing since everything is good. Nerves have settled and I am really enjoying it now. I Wont blood test again for at least 3 weeks, Where I will do a full workup when mid cycle is due. Liver,Lipids, etc.

Body look. Has changed slightly. Its little softer washed out kind of look. Been told "Bigger looking". Back shows the softer look a bit more. Arms are 3cm bigger.

No bad Sides experianced.

Back

Back Week 5

[musclenz]

Looking juiced :pfft: