African mango extract

[pyro]

Anyone used this for bodybuilding purposes while cutting?

Seems to be the new big thing that everyone is going on about, seen on Dr Oz, Oprah etc.

My old mans been out of training for a good 6 months after an operation and has put on a bit of weight which he has always struggled with. Thought he would give these a go and has dropped a couple of kilos in the past 2 weeks without changing his diet or the amount of carido he can do.

Not looking to use any myself as im still bulking for ages, just curious to hear others thoughts on this new product that's come out of no where and has taken off pretty fast.

[pyro]

Bump

[crazyfacials]

Phedder...please research it for us who don't like reading

[Diab0lic]

Looks like it functions as an appetite suppressant by acting on leptin and PPARGamma. All the studies were done in Cameroon.

IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation.

Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CM, Oben JE.

Source

Laboratory of Nutrition and Nutritional Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon. jlngondi@yahoo.com

Abstract

BACKGROUND:

A recent in vitro study indicates that IGOB131, a novel seed extract of the traditional West African food plant Irvingia gabonensis, favorably impacts adipogenesis through a variety of critical metabolic pathways including PPAR gamma, leptin, adiponectin, and glycerol-3 phosphate dehydrogenase. This study was therefore aimed at evaluating the effects of IGOB131, an extract of Irvingia gabonensis, on body weight and associated metabolic parameters in overweight human volunteers.

METHODS:

The study participants comprised of 102 healthy, overweight and/or obese volunteers (defined as BMI > 25 kg/m2) randomly divided into two groups. The groups received on a daily basis, either 150 mg of IGOB131 or matching placebo in a double blinded fashion, 30-60 minutes before lunch and dinner. At baseline, 4, 8 and 10 weeks of the study, subjects were evaluated for changes in anthropometrics and metabolic parameters to include fasting lipids, blood glucose, C-reactive protein, adiponectin, and leptin.

RESULTS:

Significant improvements in body weight, body fat, and waist circumference as well as plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels were observed in the IGOB131 group compared with the placebo group.

CONCLUSION:

Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti-obesity and lipid profile modulating effects of an Irvingia gabonensis extract. The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies. Irvingia gabonensis extract may prove to be a useful tool in dealing with the emerging global epidemics of obesity, hyperlipidemia, insulin resistance, and their co-morbid conditions.

Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and leptin genes and up-regulation of the adiponectin gene.

Oben JE, Ngondi JL, Blum K.

Source

Department of Biochemistry, Faculty of Science, Laboratory of Nutrition and Nutritional Biochemistry, University of Yaoundé I, Yaoundé, Cameroon. juliusoben@hotmail.com

Abstract

BACKGROUND:

Endeavors to manage obesity have been heavily reliant on controlling energy intake and expenditure equilibrium, but have failed to curtail the overweight and obesity epidemic. This dynamic equilibrium is more complex than originally postulated and is influenced by lifestyle, calorie and nutrient intake, reward cravings and satiation, energy metabolism, stress response capabilities, immune metabolism and genetics. Fat metabolism is an important indicator of how efficiently and to what extent these factors are competently integrating. We investigated whether an Irvingia gabonensis seed extract (IGOB131) would provide a more beneficial comprehensive approach influencing multiple mechanisms and specifically PPAR gamma, leptin and adiponectin gene expressions, important in anti-obesity strategies.

METHODS:

Using murine 3T3-L1 adipocytes as a model for adipose cell biology research, the effects of IGOB131 were investigated on PPAR gamma, adiponectin, and leptin. These adipocytes were harvested 8 days after the initiation of differentiation and treated with 0 to 250 microM of IGOB131 for 12 and 24 h at 37 degree C in a humidified 5 percent CO2 incubator. The relative expression of PPAR gamma, adiponectin, and leptin in 3T3-L1 adipocytes was quantified densitometrically using the software LabWorks 4.5, and calculated according to the reference bands of beta-actin.

RESULTS:

The IGOB131 significantly inhibited adipogenesis in adipocytes. The effect appears to be mediated through the down-regulated expression of adipogenic transcription factors (PPAR gamma) [P less than 0.05] and adipocyte-specific proteins (leptin) [P less than 0.05], and by up-regulated expression of adiponectin [P less than 0.05].

CONCLUSION:

IGOB131 may play an important multifaceted role in the control of adipogenesis and have further implications in in-vivo anti obesity effects by targeting the PPAR gamma gene, a known contributory factor to obesity in humans.

The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon.

Ngondi JL, Oben JE, Minka SR.

Source

Nutrition, HIV and Health Research Unit, Department of Biochemistry, P.O. Box 812, Faculty of Science, University of Yaounde I, Cameroon. jngondi@yahoo.com

Abstract

Dietary fibres are frequently used for the treatment of obesity. The aim of this study was to evaluate the efficacy of Irvingia gabonensis seeds in the management of obesity. This was carried out as a double blind randomised study involving 40 subjects (mean age 42.4 years). Twenty-eight subjects received Irvingia gabonensis (IG) (1.05 g three time a day for one month) while 12 were on placebo (P) and the same schedule. During the one-month study period all subjects were on a normocaloric diet evaluated every week by a dietetic record book. At the end, the mean body weight of the IG group was decreased by 5.26 +/- 2.37% (p < 0.0001) and that of the placebo group by 1.32 +/- 0.41% (p < 0.02). The difference observed between the IG and the placebo groups was significant (p < 0.01). The obese patients under Irvingia gabonensis treatment also had a significant decrease of total cholesterol, LDL-cholesterol, triglycerides, and an increase of HDL-cholesterol. On the other hand, the placebo group did not manifest any changes in blood lipid components. Irvingia gabonensis seed may find application in weight lose.

[pyro]

Phedder...please research it for us who don't like reading

Have done plenty of reading and research on it and thats not what I was after, was more after opinions on anyone that's used it, or if it would actually be useful for cutting when it comes to bodybuilding.

[nzmusclemonster]

Sounds like you love african man mango.

[Diab0lic]

What does it cost?

[pyro]

$70 in shop, but I had a look around and you can get it on special form NZ online stores for around $35-40 so its reasonably priced. Sister and bro in-law actually got some in the weekend. So will post up what they think of it after a few weeks.

[train hard]

you will get better results from watercress and puha

[Diab0lic]

This guy liked it and reckoned it helped him cut

http://forum.bodybuilding.com/showthrea ... 971&page=1

Personally I reckon you'd be better off with green tea extract which is much cheaper (stacked with EC if you can get it).

Almost everything out there on this stuff is just internet marketing BS but the few legit studies and reviews that do exist seem to show it aids in fat loss (primarliy through appetite reduction it would seem) and has positive benefits on blood lipids (although this could also be due to the reduced food intake itself) and also antioxidative properties.

Comes down to cost-benefit appeal to you. If you don't have any problems sticking to a reduced calorie diet then I probably wouldn't bother as there are cheaper ways to get antioxidants and I doubt this stuff will help you noticably lose any additional fat.

If you do have issues sticking to low calorie diets and don't want to go the stim route then this could be worth a try as long as you can get it at an OK price.