NUTRATECH

[weener lad]

JR

For every study you put up saying it's a waste there is one saying it is good.

Just stating a SUPPLEMENT (yes capitals for emphasis on the supplement :pfft: ) is useless really comes down to an individuals dietary needs. Example I don't use it because I do not find it beneficial but I also know plenty of others that do take and rely on it.

A balanced response is always required

[Phedder]

I could be wrong but I've always been under the impression that glutamine supplementation is really only beneficial for those with severely compromised immune systems and holds little benefit for young healthy weight trainers.

[vracula]

http://www.bodyrecomposition.com/nutrit ... art-2.html

Glutamine and its role is mentioned in the article

"Outside of possible effects on immune system function, there’s really not much role for glutamine in terms of energy production during exercise. Consuming adequate carbohydrate (~30-60 grams per hour) with small amounts of protein (e.g. 10-12 grams of whey protein which will provide 3-4 grams of BCAA) will do more to protect immune system function than glutamine could ever do."

[JOSEF RAKICH]

JR

For every study you put up saying it's a waste there is one saying it is good.

Just stating a SUPPLEMENT (yes capitals for emphasis on the supplement :pfft: ) is useless really comes down to an individuals dietary needs. Example I don't use it because I do not find it beneficial but I also know plenty of others that do take and rely on it.

A balanced response is always required

No there is not a single study that i have seen saying glutamine "supplementation" is good, yeah sure there is studys proving how good glutamine itself if, i alredy know this, i know glutamine is good, but supplementing with it is just a waste.

The body produces glutamein by itself, not to mention foods (espically a bodybuilders diet) is full with glutamine and our protein shakes even more glutamine, supplementing with anymore is no going to be beneficial in anyway..

[Phedder]

No there is not a single study that i have seen saying glutamine "supplementation" is good, yeah sure there is studys proving how good glutamine itself if, i alredy know this, i know glutamine is good, but supplementing with it is just a waste.

Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control

Wischmeyer, Paul E. MD; Lynch, James BS; Liedel, Jennifer MD; Wolfson, Rachel MD; Riehm, Jacob; Gottlieb, Lawrence MD; Kahana, Madelyn MD

Abstract

Objective : To determine the effect of intravenous glutamine supplementation vs. an isonitrogenous control on infectious morbidity in severely burned patients. Previous clinical studies in seriously ill patients suggest a beneficial effect of glutamine on infectious morbidity, but no trials have examined possible clinical benefits in severely burned patients.

Design : Prospective, double-blind, randomized trial.

Setting : Burn intensive care unit of a university hospital.

Patients : Twenty-six severe burn patients with total burn surface area of 25% to 90% and presence of full-thickness burns. Patients were evaluated for occurrence of bacteremia and antibiotic use during the first 30 days of their burn unit admission. Nutritional status and overall inflammation were also measured.

Intervention : Either intravenous glutamine or an isonitrogenous control amino acid solution was administered as a continuous infusion during burn intensive care unit stay.

Measurements and Main Results : The incidence of Gram-negative bacteremia was significantly reduced in the glutamine-supplemented group (8%) vs. control (43%;p < .04). No difference was seen in the incidence of Gram-positive bacteremia or fungemia. Average number of positive blood cultures, antibiotic usage, and mortality rates also were reduced but did not reach statistical significance. Significant improvements in serum transferrin and prealbumin were observed in glutamine-supplemented patients at 14 days after burn injury (p < .01 and .04, respectively). C-reactive protein was also significantly reduced at 14 days after burn injury in the glutamine group (p < .01).

Conclusions : Significantly fewer bacteremic episodes with Gram-negative organisms occurred in the glutamine-supplemented patients. Glutamine supplementation improved measures of nutrition and decreased measures of overall inflammation. In addition, a trend toward lower mortality rate, decreased overall bacteremia incidence, and antibiotic usage in the glutamine group was observed. Glutamine’s beneficial effects may be a result of improved gut integrity or immune function, but the precise mechanism of glutamine’s protection is unknown.

Glutamine supplementation in serious illness: A systematic review of the evidence *

Novak, Frantisek MD; Heyland, Daren K. MD, FRCPC, MSc; Avenell, Alison MD, MRCP, MRCPath, MB BS, MSc; Drover, John W. MD, FRCSC; Su, Xiangyao PhD

Abstract

Objective: To examine the relationship between glutamine supplementation and hospital length of stay, complication rates, and mortality in patients undergoing surgery and experiencing critical illness.

Data Sources: Computerized search of electronic databases and search of personal files, abstract proceedings, relevant journals, and review of reference lists.

Study Selection: We reviewed 550 titles, abstracts, and articles. Primary studies were included if they were randomized trials of critically ill or surgical patients that evaluated the effect of glutamine vs. standard care on clinical outcomes.

Data Extraction: We abstracted relevant data on the methodology and outcomes of primary studies in duplicate, independently.

Data Synthesis: There were 14 randomized trials comparing the use of glutamine supplementation in surgical and critically ill patients. When the results of these trials were aggregated, with respect to mortality, glutamine supplementation was associated with a risk ratio (RR) of 0.78 (95% confidence interval [CI], 0.58–1.04). Glutamine supplementation was also associated with a lower rate of infectious complications (RR, 0.81; 95% CI, 0.64–1.00) and a shorter hospital stay (−2.6 days; 95% CI, −4.5 to −0.7). We examined several a priori–specified subgroups. Although there were no statistically significant subgroup differences detected, there were some important trends. With respect to mortality, the treatment benefit was observed in studies of parenteral glutamine (RR, 0.71; 95% CI, 0.51–0.99) and high-dose glutamine (RR, 0.73; 95% CI, 0.53–1.00) compared with studies of enteral glutamine (RR, 1.08; 95% CI, 0.57–2.01) and low-dose glutamine (RR, 1.02; 95% CI, 0.52–2.00). With respect to hospital length of stay, all of the treatment benefit was observed in surgical patients (−3.5 days; 95% CI, −5.3 to −1.7) compared with critically ill patients (0.9 days; 95% CI, −4.9 to 6.8).

Conclusion: In surgical patients, glutamine supplementation may be associated with a reduction in infectious complication rates and shorter hospital stay without any adverse effect on mortality. In critically ill patients, glutamine supplementation may be associated with a reduction in complication and mortality rates. The greatest benefit was observed in patients receiving high-dose, parenteral glutamine.

Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*

Garrel, Dominique; Patenaude, Julie; Nedelec, Bernadette; Samson, Louise; Dorais, Judy; Champoux, Julie; D’Elia, Michele; Bernier, Jacques

Abstract

Objective: Enteral glutamine supplements have been shown to reduce infectious morbidity in trauma patients, but their effect on burn patients is not known. The objective of this study was to measure the impact of enteral glutamine supplementation on infectious morbidity, length of care, and the immune system in burn patients.

Design: Double-blinded, randomized clinical trial.

Setting: Burn center.

Patients: Forty-five adults with severe burns.

Interventions: Patients were randomized to receive either glutamine or an isonitrogenous control mixture until complete healing occurred. Length of care, incidence of positive blood culture, and mortality were recorded. Phagocytosis by circulating polymorphonuclear cells was measured every 3 days.

Measurements and Main Results: Patient characteristics were similar in both groups. Four patients were excluded from the analysis, because three of them died within 72 hrs and the fourth could not receive enteral nutrition and amino acid supplements for the first 10 days. Of the remaining 41 patients, length of care in the survivors was not different between groups (0.9 vs. 1.0 days/percent total body surface area for glutamine vs. control, respectively), positive blood culture was three times more frequent in control than in glutamine treatment (4.3 vs. 1.2 days/patient, p < .05), and Pseudomonas aeruginosa was detected in six patients on control and zero on glutamine (p < .05). Phagocytosis by polymorphonuclear cells was not different between groups. Mortality rate was significantly lower in glutamine than in control: intention to treat, two vs. 12 (p < .05); per protocol analysis, zero vs. eight (p < .01).

Conclusions: Enteral glutamine supplementation in adult burn patients reduces blood infection by a factor of three, prevents bacteremia with P. aeruginosa, and may decrease mortality rate. It has no effect on level of consciousness and does not appear to influence phagocytosis by circulating polymorphonuclear cells.

Glutamine supplementation can be very beneficial in a clinical setting. It's use in healthy individuals is more questionable. If someone feels it makes a difference for them that's great, personally I never noticed any benefits. For some it may be well worth it simply from a peace of mind/placebo perspective.

[JOSEF RAKICH]

No there is not a single study that i have seen saying glutamine "supplementation" is good, yeah sure there is studys proving how good glutamine itself if, i alredy know this, i know glutamine is good, but supplementing with it is just a waste.

Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control

Wischmeyer, Paul E. MD; Lynch, James BS; Liedel, Jennifer MD; Wolfson, Rachel MD; Riehm, Jacob; Gottlieb, Lawrence MD; Kahana, Madelyn MD

Abstract

Objective : To determine the effect of intravenous glutamine supplementation vs. an isonitrogenous control on infectious morbidity in severely burned patients. Previous clinical studies in seriously ill patients suggest a beneficial effect of glutamine on infectious morbidity, but no trials have examined possible clinical benefits in severely burned patients.

Design : Prospective, double-blind, randomized trial.

Setting : Burn intensive care unit of a university hospital.

Patients : Twenty-six severe burn patients with total burn surface area of 25% to 90% and presence of full-thickness burns. Patients were evaluated for occurrence of bacteremia and antibiotic use during the first 30 days of their burn unit admission. Nutritional status and overall inflammation were also measured.

Intervention : Either intravenous glutamine or an isonitrogenous control amino acid solution was administered as a continuous infusion during burn intensive care unit stay.

Measurements and Main Results : The incidence of Gram-negative bacteremia was significantly reduced in the glutamine-supplemented group (8%) vs. control (43%;p < .04). No difference was seen in the incidence of Gram-positive bacteremia or fungemia. Average number of positive blood cultures, antibiotic usage, and mortality rates also were reduced but did not reach statistical significance. Significant improvements in serum transferrin and prealbumin were observed in glutamine-supplemented patients at 14 days after burn injury (p < .01 and .04, respectively). C-reactive protein was also significantly reduced at 14 days after burn injury in the glutamine group (p < .01).

Conclusions : Significantly fewer bacteremic episodes with Gram-negative organisms occurred in the glutamine-supplemented patients. Glutamine supplementation improved measures of nutrition and decreased measures of overall inflammation. In addition, a trend toward lower mortality rate, decreased overall bacteremia incidence, and antibiotic usage in the glutamine group was observed. Glutamine’s beneficial effects may be a result of improved gut integrity or immune function, but the precise mechanism of glutamine’s protection is unknown.

Glutamine supplementation in serious illness: A systematic review of the evidence *

Novak, Frantisek MD; Heyland, Daren K. MD, FRCPC, MSc; Avenell, Alison MD, MRCP, MRCPath, MB BS, MSc; Drover, John W. MD, FRCSC; Su, Xiangyao PhD

Abstract

Objective: To examine the relationship between glutamine supplementation and hospital length of stay, complication rates, and mortality in patients undergoing surgery and experiencing critical illness.

Data Sources: Computerized search of electronic databases and search of personal files, abstract proceedings, relevant journals, and review of reference lists.

Study Selection: We reviewed 550 titles, abstracts, and articles. Primary studies were included if they were randomized trials of critically ill or surgical patients that evaluated the effect of glutamine vs. standard care on clinical outcomes.

Data Extraction: We abstracted relevant data on the methodology and outcomes of primary studies in duplicate, independently.

Data Synthesis: There were 14 randomized trials comparing the use of glutamine supplementation in surgical and critically ill patients. When the results of these trials were aggregated, with respect to mortality, glutamine supplementation was associated with a risk ratio (RR) of 0.78 (95% confidence interval [CI], 0.58–1.04). Glutamine supplementation was also associated with a lower rate of infectious complications (RR, 0.81; 95% CI, 0.64–1.00) and a shorter hospital stay (−2.6 days; 95% CI, −4.5 to −0.7). We examined several a priori–specified subgroups. Although there were no statistically significant subgroup differences detected, there were some important trends. With respect to mortality, the treatment benefit was observed in studies of parenteral glutamine (RR, 0.71; 95% CI, 0.51–0.99) and high-dose glutamine (RR, 0.73; 95% CI, 0.53–1.00) compared with studies of enteral glutamine (RR, 1.08; 95% CI, 0.57–2.01) and low-dose glutamine (RR, 1.02; 95% CI, 0.52–2.00). With respect to hospital length of stay, all of the treatment benefit was observed in surgical patients (−3.5 days; 95% CI, −5.3 to −1.7) compared with critically ill patients (0.9 days; 95% CI, −4.9 to 6.8).

Conclusion: In surgical patients, glutamine supplementation may be associated with a reduction in infectious complication rates and shorter hospital stay without any adverse effect on mortality. In critically ill patients, glutamine supplementation may be associated with a reduction in complication and mortality rates. The greatest benefit was observed in patients receiving high-dose, parenteral glutamine.

Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*

Garrel, Dominique; Patenaude, Julie; Nedelec, Bernadette; Samson, Louise; Dorais, Judy; Champoux, Julie; D’Elia, Michele; Bernier, Jacques

Abstract

Objective: Enteral glutamine supplements have been shown to reduce infectious morbidity in trauma patients, but their effect on burn patients is not known. The objective of this study was to measure the impact of enteral glutamine supplementation on infectious morbidity, length of care, and the immune system in burn patients.

Design: Double-blinded, randomized clinical trial.

Setting: Burn center.

Patients: Forty-five adults with severe burns.

Interventions: Patients were randomized to receive either glutamine or an isonitrogenous control mixture until complete healing occurred. Length of care, incidence of positive blood culture, and mortality were recorded. Phagocytosis by circulating polymorphonuclear cells was measured every 3 days.

Measurements and Main Results: Patient characteristics were similar in both groups. Four patients were excluded from the analysis, because three of them died within 72 hrs and the fourth could not receive enteral nutrition and amino acid supplements for the first 10 days. Of the remaining 41 patients, length of care in the survivors was not different between groups (0.9 vs. 1.0 days/percent total body surface area for glutamine vs. control, respectively), positive blood culture was three times more frequent in control than in glutamine treatment (4.3 vs. 1.2 days/patient, p < .05), and Pseudomonas aeruginosa was detected in six patients on control and zero on glutamine (p < .05). Phagocytosis by polymorphonuclear cells was not different between groups. Mortality rate was significantly lower in glutamine than in control: intention to treat, two vs. 12 (p < .05); per protocol analysis, zero vs. eight (p < .01).

Conclusions: Enteral glutamine supplementation in adult burn patients reduces blood infection by a factor of three, prevents bacteremia with P. aeruginosa, and may decrease mortality rate. It has no effect on level of consciousness and does not appear to influence phagocytosis by circulating polymorphonuclear cells.

Glutamine supplementation can be very beneficial in a clinical setting. It's use in healthy individuals is more questionable. If someone feels it makes a difference for them that's great, personally I never noticed any benefits. For some it may be well worth it simply from a peace of mind/placebo perspective.

Yes exctally, in a clinical setting.

But supplementing with glutamine to achive muscle hypertrophy or muscle recovery is non effective because we alredy get more than enough glutamine through our diets and if not our body produces it naturally anyway, supplementing with any more has no effect on improving body composition and you will not 'recover' any faster etc, etc,

So basically supplementing with glutamine for bodybuilding is not doing anything.