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insulin do we need it

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Insulin is one of the most powerful anabolic agents in the world. Used properly, it can add weight to you more quickly than any other compound at our disposal.

Used improperly, insulin will kill you.

Before I delve too deeply into explaining this compound, I feel that it´s important to stress that last part: Screw up with this stuff, and you die. You will go into a coma, and die. And I´m talking about simply taking too much of this stuff once.


This drug needs to be treated with caution. If you aren´t willing to read as much as possible on insulin before using it, then you aren´t ready to use it at all.

So first, let´s talk about the insulin that´s floating around in your body right now, and what it does; then we´ll talk about how adding exogenous insulin (insulin from outside your body) could possibly help you.

Insulin is a protein secreted by the pancreas which acts on the liver to stimulate the formation of glycogen from glucose and to inhibit the conversion of non-carbohydrates into glucose. Insulin also promotes facilitated diffusion of glucose through cells with insulin receptors, and of course this means muscle tissue (1). As you may expect, very high concentrations of insulin have been soundly result in markedly stimulated muscle protein synthesis (2)(3)(4)(9). It does this mainly at the translational level by enhancing peptide chain initiation (11). This property and it´s consequent results are probably the things which makes it most interesting to bodybuilders and athletes. This is because those factors combine to make ingested protein more efficient by promoting the transport of amino acids into muscle cells. Ergo, we can clearly say that insulin is undoubtedly anabolic in muscle tissue. It also has an anabolic effect in bone, and thereby increases bone density as well (8). Another mechanism by which insulin is anabolic is via increasing your body´s IGF (Insulin-like Growth Factor) levels (6). IGF is an extremely anabolic hormone.

Another unexpected aspect of insulin use is its ability to increase both LH (Leutenizing Hormone) and FSH (Follicle Stimulating Hormone), both of which in turn stimulate testosterone production. What I´m getting at here is that insulin stimulates gonadotropin secretion, meaning that it´s use may actually provide an anabolic effect through increasing your HPTA´s ability to stimulate the production of testosterone (Hypothalamic-Pituitary-Testicular-Axis)(11) This effect is often manifested as virilization (development of male sexual characteristics) in women. Insulin also increases the binding ability of anabolic steroids to the androgen receptors (14),which would clearly suggest strongly the possibility of a synergistic effect of insulin when combined with steroids. Most people also think that insulin has some anabolic synergy when combined with growth hormone, and certainly there is a lot of anecdotal evidence for this as well. In addition to anecdotal research, it´s important to note that Insulin is actually so anabolic that some researchers have speculated that Growth Hormone´s (GH) ability to stimulate Protein Synthesis may actually be,in part, due to GH´s ability to increase insulin sensitivity (12). Certainly the complex relationship between insulin, IGF, and GH is very synergistic and all interrelated to each other´s actions (13) (15) (16) (17). Using all three of them plus anabolic steroids and a fat-burner is the most potent muscle-building & fat -burning cycle possible.

Of course, when something seems too good to be true, it usually is. Unfortunately, the bad news is that insulin can easily stimulate adipose (fat) storage. Generally, though, most bodybuilders take insulin with a fat burner or 2 (Thyroid meds are the most popular choice), as well as anabolic steroids and sometimes even GH and IGF, for reasons previously explained. All of this adds up to decreasing the chance that fat is stored, and greatly increases the amount of muscle that will be gained.

Anyway, as you probably guessed, endogenous insulin (the stuff naturally found in your body) operates on feedback from within your body.

When your glucose levels get high, which is what happens when you eat a sugary snack, insulin is then released from your beta cells. When glucose is low, insulin is, of course, low.

In fact, simply adding liquid glucose to a liquid amino-acid meal (thereby raising insulin levels) will increase the absorption of the ingested amino acids by roughly 50%!(7) Now, think about this: If a natural insulin response to ingested glucose can give you 50% better absorption of protein, think about how much protein absorption injecting it will give you..

So, now that we have some kind of understanding as to what endogenous insulin does, lets try to figure out exactly what exogenous insulin can do (that´s the kind you get from a bottle..). Medically, of course, insulin is used to treat diabetes...thus becoming diabetic is a real risk with improper insulin usage.

First, I´m going to give you some clinical examples of how insulin has been used as an anti-catabolic agent. In the first study I read, insulin levels were increased 15-fold in infants suffering extreme catabolism. This level of insulin administration produced a 32% reduction in protein breakdown (4). In the second study I read exogenous insulin impeded muscle protein loss in burn victims (5). It´s important to note that you MUST have enough amino acids (protein) in your body for insulin to exert an anabolic effect. If there are not enough amino acids floating around in your body from your last few meals, insulin will not be anabolic at all. On the other hand, If amino acid concentrations are maintained at normal or high levels as they would be in a typical athlete or bodybuilder´s diet, a net protein deposition in muscle will occur (more protein deposited in your muscle = more muscle gained). This effect of insulin depositing protein in your muscles is primarily because of an actual stimulation of protein synthesis and also owing to an inhibition of protein breakdown (10). The lesson here is that even with insulin, diet is the key to it all. You need to have enough protein in order to build muscle, regardless of how much insulin you take.

Let´s quantify this a bit. What about the anabolic and anti-catabolic properties of insulin? Can we put some solid numbers on any of this?


From the following chat, you can see that insulin puts your protein balance into a much more beneficial state, and concomitantly lowers protein degradation by inhibition of the lysosomal pathway (this is it´s anti-catabolic effect) (11) and raises protein synthesis (this is it´s anabolic effect).

Protein kinetics. Protein balance, degradation, and synthesis rates are shown (measured in nmol phenylalanine " min 1 " 100 ml 1). Values represent means ± SE for the basal (open bars) and last 30 min of the insulin infusion (filled bars) periods with the 3 different rates of amino acid infusion (in ml " min 1 " kg 1) (* P < 0.05 and ** P < 0.01 for basal vs. infusion period).(5)

What this chart tells me is that insulin can efficiently utilize a great deal of protein above and beyond what your body could normally utilize, and that if you should decide to use insulin, you should be taking in at least 2.2g/kg of bodyweight, and preferably 3-4.5g/kg of bodyweight.

So now we know how & why insulin works, and how well it works. Ok, lets figure out how to use it. I´ll give you two basic ideas on how to safely use insulin, as well as a third "hybrid idea," and a dirty little trick on how to use insulin with a cyclic ketogenic diet, to get into ketosis earlier.

Whichever way you decide to use, remember, insulin has the ability to stimulate fat storage, so you want to make sure you are using anabolic steroids with it, as they will preferentially drive protein and nutrients towards being used for the accumulation of lean body mass over adipose tissue (fat). Personally, I also like to use a thyroid medication (Synthroid) to further insure none of my injectable insulin is going to put any fat on me. If you´ve been paying attention up until now, I´m sure I don´t have to tell you that GH and IGF are also very potent (and expensive) additions to any stack containing insulin. If all of that didn´t whet your appetite, then consider the fact that insulin, GH, and IGF are undetectable on drug tests! Currently, there´s speculative ways to test for them, but nothing consistent has been established. I suspect that many a top level "natural" bodybuilder has been helped out by insulin, GH, and IGF.

So now that we know something about insulin, let´s see what kind is most appropriate for bodybuilding or athletic purposes, as there are several types of insulin available, and choosing the correct type is of utmost importance. Basically there are 5 different types of insulin we´ll look at, and from them, we´ll pick the type which will best suit our purposes of building muscle:

Humalog and Humulin Insulin

Humalog (Insulin lispro inj.) is the fastest acting insulin available

Humulin-R (Regular Insulin) has a short duration of effect

Humulin-N (Insulin Isophane) is intermediate length insulin

Humulin-U(Medium Zinc Suspension) is another intermediate length insulin

Humulin-U, utalente (Prolonged Zinc Suspension) is Long acting insulin

(*there are also blends available of two or more of these types of insulin, in varying ratios of Long:Short or anything in-between)

Of these 6 possible choices, the first would appear to be the best and safest, but that particular type of insulin is (unfortunately) only available with a prescription, and getting it through a typical steroid source (which usually means through the mail) is not advisable, since you can not be sure it has been properly stored and refrigerated throughout the shipping and handling process. Needless to say, attempting to forge a prescription for this stuff is an exceptionally poor idea.

Our next best choice for an injectable insulin is Humulin-R, so that´s what we´re going to be using. Humulin R is available without a prescription, from any pharmacy. This stuff has a fairly rapid onset and peak, and ergo is much easier to deal with than the other forms of insulin available, some last very long, or have varying peaks and spikes throughout their duration, and as such are just too difficult to monitor and control.

The first and most obvious way to utilize insulin for it´s anabolic effect is to take a little bit with each meal, possibly 1-2iu´s up to 5-6x a day (insulin is measured in international units, not mgs as is common with anabolic steroids). This way you´d be getting the greatest benefit of insulin possible with each meal and the least risk of using too much and going into shock. Of course some bodybuilders have reported using up to 20-40iu/day, but I wouldn´t recommend this unless you are very experienced, and have your diet in perfect order. You´ll want to take in a tiny bit of essential fats, a decent amount of mixed carbs (i.e. carbs of varying glycemic indexes), and at least 40g of protein with each meal, when using this method of insulin use. And clearly, you´ll want to work up to this amount of insulin use, perhaps adding 1iu per day until you reach a level you are comfortable with. This holds true for either method of insulin use I´m presenting.

The second way you can use it is to take 1iu of insulin with your post workout meal, eventually working up to 1iu/10kgs of bodyweight. When using this method, you´ll want a post workout shake consisting of roughly 100-200g of mixed carbs and 40-50 grams of protein... nd don´t forget a small amount of essential fats with your shake. I have used insulin this way, along with anabolic steroids and a thyroid med, and have found it to enhance the gains from my cycle by around 15-20% as compared with a similar cycle which did not include insulin.

The final method is to use the first method as well as the second. SO you´d be taking in 1-2ius with each regular meal and up to 1iu/10kgs of bodyweight with your post workout meal. This would ensure maximum efficiency from each bite of food you eat, but this way is also the most dangerous, and you need to monitor your blood sugar. If you get tired after a shot you´ll need to get some mixed carbs into you quickly (Gatoraid and a few Granola bars and/or candy bars), it´s a good idea to carry those kinds of things around with you as insurance that your blood sugar doesn´t go too low. You also don´t want to take this stuff at night before bed, because you won´t know if your blood sugar is going low and that´s making you drowsy (meaning you could be facing hypoglycemia, and about to go into a coma) or you are just tired because it´s your normal bedtime.

And as for that dirty little trick I was telling you about...a small amount of insulin may be taken when starting a cyclic ketogenic diet, with your first meal of the day you begin. This meal would be fats and proteins, without carbs, and only 2-4iu of insulin would be taken. The following meal, you can use half the dose of insulin as you did at your first meal. The result would be that you could be in ketosis before the end of that first day, where as usually it would take 2 or even up to 3 days to accomplish this. Using insulin in this manner is very dangerous, and was even called "Death Wish Dieting" by Dan Duchaine..

Whichever method you use, remember to keep your insulin refrigerated, as Insulin will degrade very quickly outside of a refrigerated environment. Don´t leave this stuff out of the fridge too long, either.

Insulin Syringes

The other thing you don´t want to do is use regular syringes to inject insulin. You NEED insulin pins to accurately dose this stuff, remember, too much can be deadly, and the syringes you would use to inject steroids are too big to measure out units of insulin with. Insulin is given via a subcutaneous injection (below the skin but above the muscle), and regular needles are just too big to do that.

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Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-times injections, insulin will help to bring glycogen and other nutrients to the muscle.

Actrapid ® MC is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer period and can put the user in an unexpected state of hypoglycemia.

Hypoglycemia occurs when blood glucose levels are too low. It is a common and potentially fatal reaction experienced by insulin users. Before an athlete begins taking insulin, it is critical that he understands the warning signs and symptoms of hypoglycemia. The following is a list of symptoms which may indicate a mild to moderate hypoglycemia: hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling in the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personality changes. If any of these warning signs should occur, an athlete should immediately consume a food or drink containing sugar such as a candy bar or carbohydrate drink. This will treat a mild to moderate hypoglycemia and prevent a severe state of hypoglycemia. Severe hypoglycemia is a serious condition that may require medical attention. Symptoms include disorientation, seizure, unconsciousness, and death.

Insulin is used in a wide variety of ways. Most athletes choose to use it immediately after a workout. Dosages used are usually 1 IU per 10-20 pounds of lean bodyweight. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout. This will allow the athlete to safely determine a dosage. Insulin dosages can very significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone can thyroid will have higher insulin requirements, and therefore, will be able to handle higher dosages.

Humilin R should be injected subcutaneously only with a U-100 insulin syringe. Insulin syringes are available without a prescription in many states. If the athlete cannot purchase the syringes at a pharmacy, he can mail order them or buy them on the black market. Using a syringe other than a U-100 is dangerous since it will be difficult to measure out the correct dosage. Subcutaneous insulin injections are usually given by pinching a fold of skin in the abdomen area. To speed up the effect of insulin, many athletes will inject their dosage into the thighs or triceps.

Most athletes will bring their insulin with them to the gym. Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely go into a state of hypoglycemia.

Many athletes will get sleepy after injecting insulin. This may be a symptom of hypoglycemia, and an athlete should probably consume more carbohydrates. Avoid the temptation to go to bed since the insulin may take its peak effect during sleep and significantly drop glucose levels. Being unaware of the warning signs during this slumber, the athlete is at a high risk of going into a state of severe hypoglycemia without anyone realizing it. Humulin R usually remains active for only 4 hours with a peak at about two hours after injecting. An athlete would be wise to stay up for the 4 hours after injecting.

Rather than waiting to the end of a workout, many athletes prefer to inject their insulin dosage 30 minutes before their training session is over and then consume a carbohydrate drink immediately following the workout. This will make the insulin more efficient at bringing glycogen to the muscles, but it will also increase the danger of hypoglycemia. Some athletes will even inject a few IUs before lifting to improve their pump. This practice is extremely risky and best left to athletes with experience using insulin. After the injection, they will consume a carbohydrate drink and then have breakfast within the next hour. Some athletes find this application of insulin very beneficial for putting on mass, while others will tend to put on excess fat using insulin in this way.

Insulin use cannot be detected during a drug test. For this reason, along with the fact that it is cheap and readily available, insulin has become a popular drug among the competitive athlete. However, before an athlete attempts to use insulin, he should educate himself and make himself aware of the consequences.

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The Ultimate "No Fat Gain" Insulin Program

by Oliver Starr

Thanks to guys like Dr. Atkins and "Zone" author Barry Sears, everyone now knows that insulin makes you fat. Just eating in a way that causes excessively high insulin levels can pack on the pounds faster than a bodybuilder can suck down a pizza after the night show. The thing is, insulin is also the most anabolic hormone there is, period.

Sure, you say, GH packs on muscle. So do many steroids. Both true. But the really massive guys on the pro circuit will tell you the truth if you can ever get their confidence. None of them have ever gotten really, truly massive without adding insulin to their stacks. They’ll also tell you, however, that nothing else made them as FAT as using insulin. This is because insulin drives protein and carbohydrate into muscle but insulin also shunts tons of fat into adipose tissue storage if you give it the chance.

One night, Mike Zumpano and Dan Duchaine and I were sitting around having one of our philosophical discussions on the various idiosyncrasies of various anabolic pharmaceuticals. For some reason the talk turned to insulin. Horrified at the idea of having any fat on my body whatsoever (okay, maybe I’m small but I’m LEAN), I immediately said, no way! That stuff makes you FAT!

Mike was more philosophical. He suggested that the ideal way to use insulin would be to set up a bilateral IV drip of straight parenteral amino acids (DO NOT TRY THIS AT HOME!!!!!) and after it had been running into your veins for a while, take a lethal injection of insulin…This, Mike said would get you huge. Dan suggested that if he were doing this, he’d give the guy the injection in a freckle so it wouldn’t show in case he died!

While I concurred that such might be the ideal strategy, I was hard pressed to agree that the risks were in alignment with the potential benefits. I tried to get the conversation to turn towards a less ludicrous topic. "Mike, I said, why does insulin make these guys so fat?

His response was that it wasn’t insulin, it was fear. This made zero sense to me, so I pressed him on it. He explained that most of the fat gain is caused by excess carbohydrate consumption during insulin use. The common dictum is that to use insulin safely, one must concurrently consume a minimum of 10 grams of carbohydrate for each IU of insulin used. Thus, for a bodybuilder using 8 IU’s of insulin 2 times a day, in addition to his normal intake of fat and protein and carbs, he would need to consume a minimum of 160 grams of extra carbohydrate to keep him from going into a hypoglycemic coma. You’d hardly expect that 160 extra grams of carbs, or 640 extra calories per day would make a significant difference to someone already eating 5000 or more calories per day. In most cases it wouldn’t, but that’s not what Mike felt was happening in the real world.

The thing is, most bodybuilders have a high degree of fear about going into insulin shock. So they have a tendency to be somewhat reactive to any change in mental state following an injection. This leads to a much more substantial intake of carbs than simply the 10 grams per IU.

Though this amount of additional carbohydrate does not seem terribly excessive, I was certain that it was the primary reason why insulin users gained a lot of size but also a disproportionate amount of fat. In discussing this with Mike Zumpano, several things occurred to us. First, what was the rationale behind this dosage of carbohydrate? Second, did consuming this amount of carbohydrate have a basis in human biochemistry? And third, was there a more elegant solution that would enable bodybuilders to use insulin safely for anabolic effect but avoid the excessive fat gains that have so far plagued users?

We both felt that there had to be a better way. Human plasma only contains about 5 grams of carbohydrate at any one time. Diabetics that have taken too much insulin can usually get their blood sugar levels back into normal range by consuming as little a five grams (only 20 calories!) of dextrose. IF that was the case, then how did we arrive at the 10-gram per IU rule?

A New and Dangerous Method for "No Fat Gain" Insulin Use

Okay, so maybe it’s not terribly dangerous (provided you do it exactly like I say here), but it takes a hell of a lot of discipline to do it this way. The pay-off is a big muscle gain with a minimal fat gain. Is it worth it? You be the judge.

Here’s the trick; take your insulin, but only follow a LOW CARB DIET. That’s right, LOW. As in less then 50 grams of carbs per day low! Insanity? Let me explain the biochemical rationale and you can decide for yourself.


When I became convinced that insulin was preferentially repartitioning carbs into adipose tissue storage, I asked myself if there was some other way to maintain moderate blood sugar with a high degree of stability. My answer was gluconeogenesis. If you look on a biochemical pathways chart (Boehinger’s is my personal favorite), you can clearly see that when hepatic and muscle glycogen stores are depleted, but before the body drops into ketosis, the body begins to convert amino acids into glucose to maintain blood glucose levels. This process is known as gluconeogenesis.

By eating a very low carbohydrate diet, you set the stage for a depletion of hepatic and muscular glycogen stores. This up-regulates the enzymes necessary for rapid and efficient conversion of amino acids (read protein) into glucose. The word gluconeogenesis literally means "the birth of new glucose."

The second half of the equation of course, is protein. If you aren’t eating many carbs, the only way your body can produce glucose is to convert the building blocks of proteins (amino acids) into glucose. This happens to some degree whenever you eat protein, however, when you eat a huge amount of protein, even more glucose is created.

It is the glucose created from excess protein that keeps you off the floor when using insulin on a low carb diet. The thing is, we’re not talking ordinary protein consumption here, we’re talking about taking massive, I mean ludicrously huge, amounts of protein. In fact, any company that sells whey protein should be loving me after I finish this article, because there is no way that you’ll be able to eat the amount of protein that you require to do this correctly from normal food. As an example, you’d need to eat roughly 24 chicken breast a day to get the amount of protein that I found necessary to support the level of gluconeogenesis that you are going to need to use insulin with low carbs safely.

Working with a number of top athletes to refine this program, we discovered that the best strategy was to consume 600 grams of protein from a combination of whey protein and casein, plus one solid meal that contained another 50 to 100 grams of protein, plus some fiber from green leafy vegetables. The remainder of the calories need to come from fats that have no, or at least very little, carbohydrate. This means no nuts…nuts have carbs.

Another thing that you need to remember is that you need to consume a ton of water on this program - somewhere between 1 and a half and 2 gallons every day in addition to the water you get from your protein drinks. Rather then break it up into a drink every 30 minutes to an hour, mix up a 2-quart container with 100 grams of protein and keep a checklist of how many times you empty it each day.

Another thing I’ve heard from the athletes that have used this regimen (aside from how much muscle they gained) was that they started to hate any protein drink they used, no matter how good it tasted when they started. My suggestion is to find the absolute blandest protein that you can possibly find…trust me, it will taste terrible at first, but after a few weeks of slugging it down day in and day out, it will taste less terrible than the tasty drink you used to think you liked.

Another thing that I heard fairly frequently was that not only did people get bigger; they also reported getting significantly stronger. My suspicion is that there was some sort of up-regulation of glycogen storage associated with using insulin and low carbs.

Downsides: probably the worst thing about this is the discipline it requires to consume this much protein day in and day out. Remember though, on this protocol, the only thing keeping you off the floor is your intake of protein. If you use the insulin and don’t maintain adequate protein intake, either you’re going to pass out and get a trip to the hospital, or break down and chow on some carbs to maintain blood sugar. If you do this, you need to stop using the insulin and spend at least a few days carb depleting before you begin the program again.

Remember, this program isn’t for everybody. It is difficult and potentially dangerous and you will need to apply every ounce of discipline you possess to make it through it. However, if you have the will power, the results may be everything you’ve hoped for and more.


SIDEBAR: Theoretical Approach to Low Carb Insulin Use, Step by Step.

Days one through three: Carb depletion. You need to cut your carbs down to below 100 grams per day. I suggest taking them as low as 50 grams of carbs on day 3. You should also be increasing protein intake from your normal daily protein intake to 450 grams of protein per day.

Days four through 30: Protein needs to be at or above 600 grams per day. Carbs need to be held to less than 100 grams (50 is better) and you should use fats to make up the balance of your daily caloric requirements. As I said, I strongly recommend use of protein powders of mixed composition (Whey and Casein), though you can use some whole foods, too, if you wish. (Just keep in mind that 600 grams of protein from chicken breasts is about 24 chicken breasts a day!)

I recommend 2 insulin injections per day, depending upon when you train. One should be done during your workout, roughly 30 minutes before you’re finished training. The other should be taken either several hours before your workout (for those that train in the afternoon) or several hours after (if you train in the morning).

I suggest starting with a very small dose of insulin (4 IU’s) and gradually increasing it. (By the end of my program I was using 12 IU’s 3 times a day, but by this point I’m convinced that I was becoming somewhat insulin resistant).

It goes without saying that insulin should be injected subcutaneously (which shouldn’t be an issue unless you are also using GH or some other drug with an IV administration protocol. In this case, label stuff so you don’t screw up!)

I suggest that you discontinue the insulin and protein regimen within 26 days making it an even 30 for the entire cycle. If you have results even remotely approximating mine, you should have added 10 or more pounds of serious muscle!

Notes: Especially the first few times you use insulin (and any time you increase your dosage) have a friend monitor you for any signs of impending hypoglycemic event. Have those diabetic glucose or dextrose tabs available (you can find them at any pharmacy). If you find that you are feeling sleepy and dopey after taking the insulin, that’s okay, but be good about self-monitoring. If you start to lose your ability to stay awake, take a glucose tablet.

If you find yourself feeling hungry and alert after taking the insulin, one of two things are happening - either you did not take enough, or especially if it’s later in the cycle, you might be getting insulin resistant. In this case, I strongly suggest that you go off the insulin altogether and even consider a drug to improve insulin sensitivity, such as Rezulin

Lastly, BE CAREFUL. Insulin use is widely recognized as one of the riskiest frontiers of drug aided physique enhancement, and for good reason. If you don’t have the discipline to keep the carbs low and consume the required amount of protein EVERY SINGLE DAY, I suggest you stick to safer and saner methods for growing muscle.

Source: mesomorphosis.com

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More info:

CYCLEON09-28-2001, 09:38 PM

By AnabolicDiabetic (EF)



Insulin is a hormone produced in the pancreas- islet cells/beta cells to be specific. Insulin facilitates the use of sugar, which all calories are ultimately converted to, for the multitude of bodily fuctions which include energy production, brain activity, metabolism regulation- basically all of your body's function either directly or indirectly.


Humilin R is available OTC just about everywhere and while it is a quick acting insulin, it is not the fastest or most consistent in terms of absorption and effect. Humilin R starts working in about 1/2 hour and the effect can last up to six hours.

Humalog is available OTC in some states/countries while be RX only in many other states. Humalog is a true fast acting insulin which begins activity within 15 minutes and ends activity within 4 hours. Humalog is the preffered insulin to use since it works more predictably and is out of your system faster which makes it easier to control.


In general, Insulin costs between $20-$30 depending on the type and where you buy it.


Use 29 guage, 1/2cc insulin syringes. "B-D ultra-fine" is my preference in terms of brand.


Upper back of arm, abdomen(avoid area too close to belly button), inner and outer upper thigh, butt cheeks.


Rotate injection sites each time you inject. Don't inject into the same area two times in a row. Insulin injections are subcutaneous- not intramuscular.


Start with 2-3 units of insulin. There is no need to start higher than this as you will be adjusting your dose gradually to find a tolerable level.


To move your dose higher in order to find your ideal dose, go up by one unit per day. A very general guide would be to consider between 10 and 15 units as your pre-determined upper limit. If it turns out you want to go higher and don't have any trouble with those doses, then no harm is done and you can go higher. Don't make big leaps up in dose or assume more is better- be safe rather than sorry.


For Humilin R, the general start of activity is within a 1/2 hour but the varies ALOT!!!!! Don't assume you have tons of time to wait to eat simple sugars. Pay attention to how you feel and never wait more than 15 minutes(if that) to eat. First consume simple sugars(dextrose preffered but not the only one) in the form of some type of drink as these are most readily absorbed in my experience. A general guideline is 10 grams of carbs for each unit of insulin- MINIMUM! Within a hour or so after your dose you want to eat a mix of simple carbs and high protein- this is the golden hour AFTER your workout when the insulin will shuttle nutrients into your muscles very efficiently. Humilin R will peak at two hours after you take it so you must eat another balanced meal at the hour and a half mark approximately. This meal should include complex carbs, some fats, and protein. Use simple carbs also if you feel any hypoglycemic symptoms. "R" will last up to six hours so be aware of how you feel and eat as needed after the two hour mark. REMEMBER THAT YOU STILL HAVE A SIGNIFICANT AMOUNT OF INSULIN WORKING UP TO SIX HOURS LATER SO DON'T BE COMPLACENT AND ASSUME YOU'RE NOT GOING TO GO HYPOGLYCEMIC.

For Humalog, use the same general rules and type of meal sequence, but begin the process immediately. Simple carbs should be ingested within 10 minutes- NO EXCEPTIONS. Then have the carb/protein meal within the hour. Then have the balanced meal of complex carbs/fats/protein at the hour 1/2 mark. Keep aware of how you feel up to four hours after your dose and eat as needed.


The abdomen is generally the area where insulin is absorbed the most consistently or evenly as it is designed to be.

Injections near a muscle that you have worked out can dramtically increase the absorption rate and effect of your dose of insulin.

GH will make you more insulin INsensitive so your tolerance of insulin will change when on or off of GH.

Highly androgenic steroids also make you more insulin insensitive, however, can also cause very random hypoglycemia aswell.

Supplements such as Chromium, Ginseng, Alpha Lipoic Acid, and Cinnamon (among others) increase insulin sensitivity.

Variations in glycogen levels in your muscles can also affect how severe a hypoglycemic reactions may be or may feel. If you are starting out with low levels of muscle glycogen, the same dose of insulin that didn't affect you before may now be too much.

The glucagon response from everyone's liver will vary. This hormone increases blood sugar when during stresses to the body or in response to hypoglycemia. Some people may get a big response from their liver and hypoglycemia for them won't be as severe. Others will have less of a respense and may be more prone to insulin shock. This response can also vary for each person based on their diet, exercise etc. so don't assume your liver will react the same way to hypoglycemia each time- you may get help from it or you may have to depend mostly on consuming sugar to save your life.


They include: sweating, dizziness, heart palpitations, tremors, drowsiness, sleep distrubances, anxiety, blurred vision, hunger, restelessness, lightheadedness, tingling in extremeties, headache, slurred speech, irritability, unstable movement, personality changes, seizures, DEATH


Insulin should be cycled so that you have less of a chance of permanently affecting your own body's production of insulin. Even cycling can affect your own production though so be aware and see your doctor regularly. I say 4 weeks on and 4 weeks off as a general rule of thumb with 6 weeks on being the absolute limit in my opinion.


This was meant to be a basic introduction to using insulin. I do not condone the use of insulin by non-diabetics nor am I encouraging anyone to use insulin. I am not a doctor and YOU are the only one who can be responsible for making the decision to use insulin. I hope this helps someone to stay safe and think things through before jumping into the unknown.

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