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Testosterone therapy in men with Crohn’s disease

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Testosterone therapy in men with Crohn's disease improves the clinical course of the disease: data from long-term observational registry study.



Crohn's disease is an inflammatory chronic bowel disease characterized by an imbalanced production of pro-inflammatory mediators (tumor necrosis factor-α) and an increased recruitment of leukocytes to the site of inflammation. Low serum testosterone is associated with an increase in inflammatory factors, while testosterone administration reduces them. There is evidence for an immunomodulatory effect of testosterone on differentiation of regulatory T cells.


Normalizing serum testosterone in hypogonadal men with Crohn's disease had a positive effect on the clinical course, also evidenced by biochemical parameters. Testosterone administration appeared safe.


doi: 10.1515/hmbci-2015-0014.

Testosterone therapy in men with Crohn’s disease.pdf

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