Pseudonym Posted October 20, 2015 Report Share Posted October 20, 2015 http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=11532246 The presence of picamilon in supplements was concerning as its effects were "entirely unpredictable", said Harvard scientist Pieter Cohen. "Why this drug would be used in a pre-workout supplement is hard to fathom, unless it's to give a pleasing sensation to the consumer that leads them to purchase more," said Dr Cohen, one of an international group of scientists that produced a research paper on picamilon published in the journal Drug Testing and Analysis. Dr Cohen's research found doses of the drug in US products - where it is legal - often deviated from what was stated. "We learned that dosages of picamilon were often much higher than even the highest prescription doses, and ... the customer would have absolutely no idea how much picamilon they were consuming by reading the label. This is a scary thought even for a consumer who didn't mind experimenting with unapproved drugs." Quote Link to comment Share on other sites More sharing options...
Bigken1985 Posted October 20, 2015 Report Share Posted October 20, 2015 oh boy, might as well just get the real deal these days, everything is banned and illegal anyway Quote Link to comment Share on other sites More sharing options...
jimmybro1 Posted October 20, 2015 Report Share Posted October 20, 2015 Oh noooo not #narlabs Quote Link to comment Share on other sites More sharing options...
Pseudonym Posted October 20, 2015 Author Report Share Posted October 20, 2015 https://en.wikipedia.org/wiki/Picamilon Interesting stuff. Apparently a dietary supplement in the US, but a prescription medicine in Russia - wait, wut?! Surely that's backwards! Still, other than the (indirect) vasodilation effects which I presume might contribute to a bigger pump, it's hard to see why it's in a pre-workout. Quote Link to comment Share on other sites More sharing options...
Daz69 Posted October 23, 2015 Report Share Posted October 23, 2015 https://en.wikipedia.org/wiki/Picamilon Interesting stuff. Apparently a dietary supplement in the US, but a prescription medicine in Russia - wait, wut?! Surely that's backwards! Still, other than the (indirect) vasodilation effects which I presume might contribute to a bigger pump, it's hard to see why it's in a pre-workout. Apparently at high doses its alleged to work as a stimulant, whereas lower dose produces sedating effects... Which is totally opposite to GHB... Picamilon is Niacin bound to GABA, this combination allows passage through the blood brain barrier, as GABA taken orally usually gets metabolised in the digestive tract... GABA by the way is one of the most abundant neurotransmitter in the CNS not a date rape drug... In theory it is possible to synthesise GHB from GABA but the Niacin bond would have to be broken first, it would be easier to purchase GABA from a health food store and save yourself the trouble.. For those interested Sandmeyer reaction uses nitrous acid to turn amines into diazonium salts, Aliphatic diazonium salts rapidly undergo hydrolysis in H2O giving off nitrogen gas leaving a hydroxyl group behind, these simple reactions can turn GABA into GHB... ;-) Quote Link to comment Share on other sites More sharing options...
maccaz Posted October 23, 2015 Report Share Posted October 23, 2015 Apparently at high doses its alleged to work as a stimulant, whereas lower dose produces sedating effects... Which is totally opposite to GHB... Picamilon is Niacin bound to GABA, this combination allows passage through the blood brain barrier, as GABA taken orally usually gets metabolised in the digestive tract... GABA by the way is one of the most abundant neurotransmitter in the CNS not a date rape drug... In theory it is possible to synthesise GHB from GABA but the Niacin bond would have to be broken first, it would be easier to purchase GABA from a health food store and save yourself the trouble.. For those interested Sandmeyer reaction uses nitrous acid to turn amines into diazonium salts, Aliphatic diazonium salts rapidly undergo hydrolysis in H2O giving off nitrogen gas leaving a hydroxyl group behind, these simple reactions can turn GABA into GHB... ;-) i also have a lot of scientific knowledge on this topic also gathering during my years spent as a scientist (or something) 1. if u drink too much ghb you get a sore stomach and your body forces it and anything else in you out via whatever avenue possible 2. its kind of stupid calling it a date rape drug, even in a strong tasting drunk its disgusting, i can safely say i have a good enough sense of taste to not be date raped. 3. use something accurate to measure it, dont try eyeball a measurement in a teaspoon Quote Link to comment Share on other sites More sharing options...
Daz69 Posted October 23, 2015 Report Share Posted October 23, 2015 i also have a lot of scientific knowledge on this topic also gathering during my years spent as a scientist (or something) 1. if u drink too much ghb you get a sore stomach and your body forces it and anything else in you out via whatever avenue possible 2. its kind of stupid calling it a date rape drug, even in a strong tasting drunk its disgusting, i can safely say i have a good enough sense of taste to not be date raped. 3. use something accurate to measure it, dont try eyeball a measurement in a teaspoon I assume you mixed yours with something like orange juice, rather than drinking it neat..?? Yeh... GHB is a weird compound, at about 1.5g it acts on GHB receptors producing a stimulant effects, about 3.5g it acts on GABA-B receptors as a CNS depressant... Its reputed to be a wonderful synergist when taken with or before other drugs... Enhancing their effect..!! Quote Link to comment Share on other sites More sharing options...
maccaz Posted October 23, 2015 Report Share Posted October 23, 2015 I assume you mixed yours with something like orange juice, rather than drinking it neat..??have tried neat (imagine thats what nail polish remover tastes like) usually orange juice but its noticeable in orange juice even. 1ml in maybe 200ml OJ? i just dont see how someone could have like wine spiked unless they were blind drunk already off topic though Quote Link to comment Share on other sites More sharing options...
crazyfacials Posted October 23, 2015 Report Share Posted October 23, 2015 In B4 someone from Gymnation walks around offering chicks preworkouts in hopes to Bill Cosby them Quote Link to comment Share on other sites More sharing options...
maccaz Posted October 23, 2015 Report Share Posted October 23, 2015 In B4 someone from Gymnation walks around offering chicks preworkouts in hopes to Bill Cosby themId give you a strike for inappropriate jokes but unfortunately the fake mods confiscated my real mod status. I was also forced to revoke gyzz strikes Quote Link to comment Share on other sites More sharing options...
crazyfacials Posted October 23, 2015 Report Share Posted October 23, 2015 Id give you a strike for inappropriate jokes but unfortunately the fake mods confiscated my real mod status. I was also forced to revoke gyzz strikesI was wondering what happened to your post, how does it feel to be Clark Kent ? Quote Link to comment Share on other sites More sharing options...
HarryB Posted November 3, 2015 Report Share Posted November 3, 2015 I personally am disgusted with the casual and callous way in which you reprehensible layabouts talk about recreational drug use. It is my most fervent hope that you all receive lengthy jail sentences. I for one will feel a lot safer in the gym knowing you reprobates are exactly where you should be.....Or something. .. Pseudonym 1 Quote Link to comment Share on other sites More sharing options...
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